Beyond binding: antibody effector functions in infectious diseases

LL Lu, TJ Suscovich, SM Fortune, G Alter - Nature Reviews Immunology, 2018 - nature.com
Antibodies play an essential role in host defence against pathogens by recognizing
microorganisms or infected cells. Although preventing pathogen entry is one potential …

[HTML][HTML] Rotaviruses

U Desselberger - Virus research, 2014 - Elsevier
Recent advances of rotavirus (RV) basic and applied research are reviewed. They consist of
determination of the RV particle structure and functions of structural proteins, classification …

Intracellular neutralisation of rotavirus by VP6-specific IgG

SL Caddy, M Vaysburd, M Wing, S Foss… - PLoS …, 2020 - journals.plos.org
Rotavirus is a major cause of gastroenteritis in children, with infection typically inducing high
levels of protective antibodies. Antibodies targeting the middle capsid protein VP6 are …

[HTML][HTML] Correlates of protection against human rotavirus disease and the factors influencing protection in low-income settings

E Clarke, U Desselberger - Mucosal immunology, 2015 - Elsevier
Rotaviruses (RV) are the leading cause of gastroenteritis in infants and children worldwide
and are associated with high mortality predominately in low-income settings. The virus is …

Rotavirus research: 2014–2020

S Caddy, G Papa, A Borodavka, U Desselberger - Virus research, 2021 - Elsevier
Rotaviruses are major causes of acute gastroenteritis in infants and young children
worldwide and also cause disease in the young of many other mammalian and of avian …

[HTML][HTML] The dark side of the gut: Virome–host interactions in intestinal homeostasis and disease

Y Li, SA Handley, MT Baldridge - Journal of Experimental Medicine, 2021 - rupress.org
The diverse enteric viral communities that infect microbes and the animal host collectively
constitute the gut virome. Although recent advances in sequencing and analysis of …

The role of nucleoprotein in immunity to human negative-stranded RNA viruses—not just another brick in the viral nucleocapsid

M Šantak, Z Matić - Viruses, 2022 - mdpi.com
Negative-stranded RNA viruses (NSVs) are important human pathogens, including
emerging and reemerging viruses that cause respiratory, hemorrhagic and other severe …

Equine herpesvirus type 1 (EHV-1) replication at the upper respiratory entry site is inhibited by neutralizing EHV-1-specific IgG1 and IgG4/7 mucosal antibodies

NA Eady, C Holmes, C Schnabel, S Babasyan… - Journal of …, 2024 - Am Soc Microbiol
ABSTRACT Equine herpesvirus type 1 (EHV-1) is a contagious respiratory pathogen that
infects the mucosa of the upper respiratory tract (URT). Mucosal immune responses at the …

Rotavirus replication: Gaps of knowledge on virus entry and morphogenesis

H Suzuki - The Tohoku journal of experimental medicine, 2019 - jstage.jst.go.jp
Abstract In 1973, rotaviruses A (RVAs) were discovered as major causative agents of acute
gastroenteritis in infants and young children worldwide. The infectious RV virion is an …

Biophysical properties of single rotavirus particles account for the functions of protein shells in a multilayered virus

M Jimenez-Zaragoza, MPL Yubero, E Martín-Forero… - Elife, 2018 - elifesciences.org
The functions performed by the concentric shells of multilayered dsRNA viruses require
specific protein interactions that can be directly explored through their mechanical …