Bioluminescence has long been used to image biological processes in vivo. This technology
features luciferase enzymes and luciferin small molecules that produce visible light …

Enzyme engineering is an important biotechnological process capable of generating
tailored biocatalysts for applications in industrial chemical conversion and biopharma …

Natural proteins are highly optimized for function but are often difficult to produce at a scale
suitable for biotechnological applications due to poor expression in heterologous systems …

Mucin-type O-glycosylation is a post-translational modification present at the interface
between cells where it has important roles in cellular communication. However, deciphering …

Increasing demands for efficient and versatile chemical reactions have prompted
innovations in enzyme engineering. A major challenge in engineering α-ketoglutarate …

Inducible protein switches are currently limited for use in tissues and organisms because
common inducers cannot be controlled with precision in space and time in optically dense …

Introducing nitrogen fixation (nif) genes into eukaryotic genomes and targeting Nif
components to mitochondria or chloroplasts is a promising strategy for engineering nitrogen …

The ability to record transient cellular events in the DNA or RNA of cells would enable
precise, large-scale analysis, selection, and reprogramming of heterogeneous cell …

Optogenetics is a powerful approach that enables researchers to use light to dynamically
manipulate cellular behavior. Since the first published use of optogenetics in synthetic …

Proteases cut with enviable precision and regulate diverse molecular events in biology.
Such qualities drive a seemingly inexhaustible appetite for proteases with new activities and …