Mental illness modeling is still a major challenge for scientists. Animal models of
schizophrenia are essential to gain a better understanding of the disease etiopathology and …

The female lifespan is marked by periods of dramatic hormonal fluctuation. Changes in the
ovarian hormones estradiol and progesterone, in addition to the progesterone metabolite …

Early life experiences play a vital role in contributing to healthy brain development. Adverse
experiences have a lasting impact on the prefrontal cortex (PFC) and basolateral amygdala …

The long-range coupling within prefrontal-hippocampal networks that account for cognitive
performance emerges early in life. The discontinuous hippocampal theta bursts have been …

The early life environment markedly influences brain and behavioral development, with
adverse experiences associated with increased risk of anxiety and depressive phenotypes …

Parvalbumin positive (PV+) interneurons play a pivotal role in cognition and are known to be
regulated developmentally and by ovarian hormones. The onset of puberty represents the …

A marked decrease in parvalbumin (PV), a calcium-binding protein specific to a subset of
GABAergic neurons, is a consistent finding in postmortem schizophrenic brain tissue. This …

Abstract Type 2 diabetes (T2D) has been associated with cognitive decline, dementia and
Alzheimer's disease (AD). Remarkably, the pathophysiological mechanisms behind this are …

Timothy syndrome (TS) is a multisystemic genetic disorder involving neuropsychiatric
symptoms. TS is caused by heterozygous functional mutations in the neurophysiologically …

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder, characterised by
deficits in verbal and non-verbal communication, social interaction and repetitive behaviours …