The transport of specific molecules across lipid membranes is an essential function of all
living organisms. The processes are usually mediated by specific transporters. One of the …

Neuroblastoma is a pediatric solid cancer of heterogeneous clinical behavior. The unique
features of this type of cancer frequently hamper the process of determining clinical …

Overexpression of ATP-binding cassette (ABC) transporters is a cause of drug resistance in
a plethora of tumors. More recent evidence indicates additional contribution of these …

Background ABC transporters have attracted considerable attention for their function as drug
transporters in a broad range of tumours and are therefore considered as major players in …

Over 80% of ovarian cancer patients develop chemoresistance which results in a lethal
course of the disease. A well-established cause of chemoresistance involves the family of …

Cancer multidrug resistance (MDR) could lead to therapeutic failure of chemotherapy and
radiotherapy, and has become one of the main obstacles to successful cancer treatment …

Background: Docetaxel is the only FDA-approved first-line treatment for castration-resistant
prostate cancer (CRPC) patients. Docetaxel treatment inevitably leads to tumour recurrence …

ATP-binding cassette (ABC) transporters mediate multidrug resistance in cancer. In contrast
to DNA single nucleotide polymorphisms in normal tissues, the role of mutations in tumors is …

Acute lymphoblastic leukemia (ALL) is the most prevalent cancer among children, and
multidrug efflux mediated by overexpression of ABC transporters is the major impediment to …

Multidrug resistance (MDR) is considered as the major obstacle for treating pediatric acute
lymphoblastic leukemia (ALL). MicroRNAs (miRNAs) are small non coding RNAs which may …