[HTML][HTML] Presynaptic adenosine receptor heteromers as key modulators of glutamatergic and dopaminergic neurotransmission in the striatum
Adenosine plays a very significant role in modulating striatal glutamatergic and
dopaminergic neurotransmission. In the present essay we first review the extensive …
dopaminergic neurotransmission. In the present essay we first review the extensive …
Unifying family A GPCR theories of activation
BG Tehan, A Bortolato, FE Blaney, MP Weir… - Pharmacology & …, 2014 - Elsevier
Several new pairs of active and inactive GPCR structures have recently been solved
enabling detailed structural insight into the activation process, not only of rhodopsin but now …
enabling detailed structural insight into the activation process, not only of rhodopsin but now …
Protein conformational plasticity and complex ligand-binding kinetics explored by atomistic simulations and Markov models
N Plattner, F Noé - Nature communications, 2015 - nature.com
Understanding the structural mechanisms of protein–ligand binding and their dependence
on protein sequence and conformation is of fundamental importance for biomedical …
on protein sequence and conformation is of fundamental importance for biomedical …
Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations
Understanding and control of structures and rates involved in protein ligand binding are
essential for drug design. Unfortunately, atomistic molecular dynamics (MD) simulations …
essential for drug design. Unfortunately, atomistic molecular dynamics (MD) simulations …
Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer
J Bonaventura, G Navarro… - Proceedings of the …, 2015 - National Acad Sciences
Adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R) heteromers are key
modulators of striatal neuronal function. It has been suggested that the psychostimulant …
modulators of striatal neuronal function. It has been suggested that the psychostimulant …
Nanobodies to study protein conformational states
Highlights•Nanobodies lock distinct conformational states of proteins.•Nanobodies stabilize
protein complexes.•Nanobodies can be functionally expressed as intrabodies to study …
protein complexes.•Nanobodies can be functionally expressed as intrabodies to study …
The Pharmacological Potential of Adenosine A2A Receptor Antagonists for Treating Parkinson's Disease
A Mori, JF Chen, S Uchida, C Durlach, SM King… - Molecules, 2022 - mdpi.com
The adenosine A2A receptor subtype is recognized as a non-dopaminergic
pharmacological target for the treatment of neurodegenerative disorders, notably …
pharmacological target for the treatment of neurodegenerative disorders, notably …
Control of glutamate release by complexes of adenosine and cannabinoid receptors
Background It has been hypothesized that heteromers of adenosine A 2A receptors (A2AR)
and cannabinoid CB 1 receptors (CB1R) localized in glutamatergic nerve terminals mediate …
and cannabinoid CB 1 receptors (CB1R) localized in glutamatergic nerve terminals mediate …
A mutagenesis and screening strategy to generate optimally thermostabilized membrane proteins for structural studies
F Magnani, MJ Serrano-Vega, Y Shibata… - Nature protocols, 2016 - nature.com
The thermostability of an integral membrane protein (MP) in detergent solution is a key
parameter that dictates the likelihood of obtaining well-diffracting crystals that are suitable for …
parameter that dictates the likelihood of obtaining well-diffracting crystals that are suitable for …
[HTML][HTML] How do adenosine A2A receptors regulate motor function?
A Mori - Parkinsonism & related disorders, 2020 - Elsevier
Adenosine A 2A receptor antagonism is a new therapeutic strategy in the symptomatic
treatment of Parkinson's disease (PD). This review addresses how adenosine A 2A …
treatment of Parkinson's disease (PD). This review addresses how adenosine A 2A …