Tissue kallikreins are a family of fifteen secreted serine proteases encoded by the largest
protease gene cluster in the human genome. In the past decade, substantial progress has …

The 15 members of the kallikrein-related serine peptidase (KLK) family have diverse tissue-
specific expression profiles and putative proteolytic functions. The kallikrein family is also …

Melanoma is the most lethal skin cancer characterized by its high metastatic potential. It is
urgent to find novel therapy strategies to overcome this feature. Metformin has been …

Epigenetic gene deregulation in cancer commonly occurs through chromatin repression and
promoter hypermethylation of tumor-associated genes. However, the mechanism …

Background Group 1 pulmonary arterial hypertension (PAH) is a rare disease with high
mortality despite recent therapeutic advances. Pathogenic remodeling of pulmonary …

Our knowledge on tissue-and disease-specific functions of human genes is rather limited
and highly context-specific. Here, we have developed a method for the comparison of mRNA …

The human tissue kallikrein and kallikrein-related peptidases (KLKs), encoded by the largest
contiguous cluster of protease genes in the human genome, are secreted serine proteases …

Including the true tissue kallikrein KLK1, kallikrein-related peptidases (KLKs) represent a
family of fifteen mammalian serine proteases. While the physiological roles of several KLKs …

Abstract Cancer-associated fibroblasts (CAFs), represent a pivotal compartment of solid
cancers (desmoplasia), and are causatively implicated in cancer development and …

Purpose Pulmonary arterial hypertension (PAH) is a rare, progressive vasculopathy with
significant cardiopulmonary morbidity and mortality. Genetic testing is currently …