Stem cell differentiation is of great interest in medical research; however, specifically and
effectively regulating stem cell differentiation is still a challenge. In addition to chemical …

Accumulating evidence indicates that most primary Wharton's jelly mesenchymal stem cells
(WJ-MSCs) therapeutic potential is due to their paracrine activity, ie, their ability to modulate …

Background The therapeutic potential of mesenchymal stem cells (MSCs) in type 1 diabetes
(T1D) has been demonstrated in both preclinical and clinical studies. MSCs that have been …

During the past decade, mesenchymal stem cells (MSCs) have made their mark as a
potential weapon in regenerative medicine. Since their first isolation by Friedenstein in the …

According to the World Health Organization, the population of over 60 will double in the next
30 years in the developed countries, which will enforce a further raise of the retirement age …

Diabetic nephropathy (DN) is one of the most common diabetes mellitus (DM) microvascular
complications, which always ends with end-stage renal disease (ESRD). Up to now, as the …

This study presents a meta-analysis that compiles information collected from several studies
aiming to prove, by evidence, that nanocarriers out-perform conventional formulations in …

Background The therapeutic efficacy of mesenchymal stem cells (MSCs) of different tissue
origins on metabolic disorders can be varied in many ways but remains poorly defined. Here …

Alzheimer's disease (AD) is a complex form of neurodegenerative dementia. Growing body
of evidence supports the cardinal role of sirtuin1 (SIRT1) in neurodegeneration and AD …

Abstract Type 1 diabetes (T1D) is a chronic autoimmune disease associated with
complications that reduce the quality of life of affected individuals and their families. The …