Dysregulated signaling from TNF and TNFR proteins is implicated in several immune-
mediated inflammatory diseases (IMIDs). This review centers around seven IMIDs …

The rise of precision cellular therapies | Nature Reviews Rheumatology Skip to main content
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Antiphospholipid syndrome is an autoimmune disorder characterized by the development of
spontaneous venous, arterial, or microvascular thrombosis and/or pregnancy-related …

Chimeric antigen receptor T (CAR-T) cell therapy, an emerging personalized
immunotherapy for various haematologic malignancies, autoimmune diseases and other …

Abstract Systemic Lupus Erythematosus (SLE) and lupus nephritis treatment is still based on
non-specific immune suppression despite the first biological therapy for the disease having …

Evidence for chimeric antigen receptor T-cell (CAR-T) treatment in systemic autoimmune
rheumatic diseases (ARDs) is limited, often based on short-term clinical investigations or …

CAR T cell therapy is showing remarkable results in autoimmune disease with treatment-
refractory patients showing durable drug-free remission. Here, we highlight five key papers …