Neuroprotective potential of Malva neglecta is mediated via down-regulation of cholinesterase and modulation of oxidative stress markers

U Saleem, R Akhtar, F Anwar, MA Shah… - Metabolic Brain …, 2021 - Springer
Alzheimer's disease affects daily routine due to loss of memory and decline in cognition. In
vitro data showed acetylcholine esterase inhibition activity of Malva neglecta but no in vivo …

MAPLE coatings embedded with essential oil-conjugated magnetite for anti-biofilm applications

O Gherasim, RC Popescu, V Grumezescu… - Materials, 2021 - mdpi.com
The present study reports on the development and evaluation of nanostructured composite
coatings of polylactic acid (PLA) embedded with iron oxide nanoparticles (Fe3O4) modified …

Effect of Natural Plant Products on Alzheimer's Disease

H Varshney, YH Siddique - CNS & Neurological Disorders-Drug …, 2024 - benthamdirect.com
Background: Plants and their extracts like ginger, garlic, Curcuma, Salvia, and Ginkgo are
best known for their anti-oxidative and anti-inflammatory responses. These plants have …

Sweroside: An iridoid glycoside of potential neuroprotective, antidiabetic, and antioxidant activities supported by molecular docking

G Zengin, M El-Raey, W El-Kashak, GES Batiha… - Amino acids, 2023 - Springer
Oxidative stress can be a series burden on human health and may lead to many chronic
diseases such as diabetes and neurological disorders. The use of natural products to …

Imperatorin exerts antioxidant effects in vascular dementia via the Nrf2 signaling pathway

X Liao, Z Zhang, M Ming, S Zhong, J Chen… - Scientific Reports, 2023 - nature.com
Imperatorin, an active ingredient extracted from Angelica and Qianghuo, has anti-
inflammatory, anti-oxidative stress damage, blocking calcium channels, and other …

[HTML][HTML] Phytochemistry, structural diversity, biological activities and pharmacokinetics of iridoids isolated from various genera of the family Scrophulariaceae Juss.

AA Thabet, IM Ayoub, FS Youssef, E Al-Sayed… - Phytomedicine Plus, 2022 - Elsevier
Background Iridoids are naturally occurring oxygenated monoterpenes with wide range of
pharmacological activities. Scrophulariaceae Juss. is a family of flowering plants with 74 …

Investigating the promising SARS-CoV-2 main protease inhibitory activity of secoiridoids isolated from Jasminum humile; in silico and in Vitro assessments with …

AA Al-Karmalawy, R Alnajjar, AA Elmaaty… - Journal of …, 2024 - Taylor & Francis
The proteolytic enzyme 3 C-like protease (3Clpro or Mpro) is considered the most important
target for SARS-CoV-2 which could be attributed to its crucial role in viral maturation and/or …

Acetyl barlerin from Barleria trispinosa induces chemopreventive NQO1 and attenuates LPS-induced inflammation: in vitro and molecular dynamic studies

HM Assiry, AR Hamed, GA Mohamed… - Journal of …, 2023 - Taylor & Francis
Extraction and fractionation of Barleria trispinosa growing in Saudi Arabia yielded four
iridoid compounds identified by spectroscopic techniques as acetylbarlerin (1), barlerin (2) …

Avanafil mediated dual inhibition of IKKβ and TNFR1 in an experimental paradigm of Alzheimer's disease: in silico and in vivo approach

P Chowdari Gurram, S Satarker, G Kumar… - Journal of …, 2023 - Taylor & Francis
In Alzheimer's disease pathology, inhibitors of nuclear factor kappa-β kinase subunit β
(IKKB) and Tumor necrosis factor receptor 1 (TNFR1) signaling are linked to …

[PDF][PDF] Mogos, anu

O Gherasim, RC Popescu, V Grumezescu - 2018 - academia.edu
The present study reports on the development and evaluation of nanostructured composite
coatings of polylactic acid (PLA) embedded with iron oxide nanoparticles (Fe3O4) modified …