Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but
whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect …

Hepatocellular carcinoma (HCC) is the most common primary malignant tumor that accounts
for~ 80% of all liver cancer cases worldwide. It is a multifactorial disease caused by a variety …

Liver fat deposition related to systemic insulin resistance defines non-alcoholic fatty liver
disease (NAFLD) which, when associated with oxidative hepatocellular damage …

Hepatitis C virus (HCV) is a major leading cause of hepatocellular carcinoma (HCC). HCV-
induced hepatocarcinogenesis is a multistep process resulting from a combination of …

Tissue fibrosis is a core pathologic process that contributes to mortality in~ 45% of the
population and is likely to be influenced by the host genetic architecture. Here we …

Hepatitis delta virus (HDV) is responsible for the most severe form of acute and chronic viral
hepatitis. We previously proposed that the Deltavirus genus is composed of eight major …

Multiple pathways of programmed cell death are important in liver homeostasis. Hepatocyte
death is associated with progression of nonalcoholic fatty liver disease, and inhibition of …

Outcomes of hepatitis C virus (HCV) infection and treatment depend on viral and host
genetic factors. Here we use human genome-wide genotyping arrays and new whole …

BACKGROUND & AIMS: Polymorphisms in IL28B were shown to affect clearance of
hepatitis C virus (HCV) infection in genome-wide association (GWA) studies. Only a fraction …

The substantial heterogeneity and hierarchical organization in liver cancer support the
theory of liver cancer stem cells (LCSCs). However, the relationship between chronic …