Naturally, in somatic cells chromosome ends (telomeres) shorten during each cell division.
This process ensures to limit proliferation of somatic cells to avoid malignant proliferation; …

Apoptosis, a form of programmed cell death, plays a very crucial role in various
physiological processes for maintaining cell homeostasis. This process has several …

Stem cell-based therapy has emerged as an attractive method for regenerating and
repairing the lost heart organ. On other hand, poor survival and maintenance of the cells …

The identification of factors that reduce the senescent tendency of the mesenchymal stem
cells (MSCs) upon expansion has great potential for cellular therapies in regenerative …

Alternative splicing (AS) of human telomerase catalytic subunit (hTERT, human telomerase
reverse transcriptase) pre-mRNA strongly regulates telomerase activity. Several proteins …

Rhodospirillum rubrum l-asparaginase mutant RrA E149R, V150P, F151T (RrA) was
previously identified to down-regulate telomerase activity along with catalyzing the …

Telomerase activity is regulated by an alternative splicing of mRNA of the telomerase
catalytic subunit hTERT (human telomerase reverse transcriptase). Increased expression of …

Telomerase can overcome replicative senescence by elongation of telomeres but is also a
specific element in most cancer cells. It is expressed more vastly than any other tumor …

As a major cancer hallmark, there is a sustained interest in understanding the telomerase
contribution to carcinogenesis in order to therapeutically target this enzyme. This is …

Regulatory T cells (Tregs) play a fundamental role in the maintenance of immunological
tolerance by suppressing effector target T, B and NK lymphocytes. Contact-dependent …