Effects of naringin on oxidative stress, inflammation, some reproductive parameters, and apoptosis in acrylamide‐induced testis toxicity in rat

E Sengul, V Gelen, S Yildirim, İ Cinar… - Environmental …, 2023 - Wiley Online Library
Acrylamide (ACR) is used in many fields such as cosmetics, paper, and textile industries. It
also occurs at very high temperatures in some foods. Gonadotoxic effects of ACR have been …

Gossypin: a flavonoid with diverse pharmacological effects

B Song, X Shen, C Tong, S Zhang… - Chemical Biology & …, 2023 - Wiley Online Library
Gossypin is a flavonoid compound prepared from chinese medicine Hibiscus, which not only
has significant pharmacological activities in antioxidant, anti‐inflammatory, neuroprotective …

In vivo and in vitro cardioprotective effect of gossypin against isoproterenol-induced myocardial infarction injury

I Cinar, M Yayla, T Tavaci, E Toktay, RA Ugan… - Cardiovascular …, 2022 - Springer
The aim of the study was to examine the protective effects and possible mechanism of
gossypin against isoproterenol (ISO)-mediated myocardial damage in vivo and H9c2 cell …

Effects of tocilizumab and dexamethasone on the downregulation of proinflammatory cytokines and upregulation of antioxidants in the lungs in oleic acid-induced …

F Terzi, B Demirci, İ Çınar, M Alhilal, HS Erol - Respiratory research, 2022 - Springer
Background Acute respiratory distress syndrome (ARDS) is a life-threatening disease
caused by the induction of inflammatory cytokines and chemokines in the lungs. There is a …

Selenium reduces acrylamide‐induced testicular toxicity in rats by regulating HSD17B1, StAR, and CYP17A1 expression, oxidative stress, inflammation, apoptosis …

S Yildirim, E Sengul, EH Aksu, İ Cinar… - Environmental …, 2024 - Wiley Online Library
This study investigated the effects of Selenium (Se) on testis toxicity induced by Acrylamide
(ACR) in rats. In our study, 50 male adult rats were used, and the rats were divided into five …

5-HT7 receptors as a new target for prostate cancer physiopathology and treatment: an experimental study on PC-3 cells and FFPE tissues

I Cinar, B Sirin, Z Halici, SS Palabiyik-Yucelik… - Naunyn-Schmiedeberg's …, 2021 - Springer
Prostate cancer (PCa) is one of the most common types of cancer seen among men
worldwide. Previous studies have demonstrated that serotonin regulates cell proliferation …

Anticancer Effects and Molecular Mechanisms of Gossypin on Phosphatidylinositol 3-Kinase/Protein Kinase B Inhibition in Human Nonsmall Cell Lung Cancer Cell …

SU Lee, YH Kim - Natural Product Communications, 2023 - journals.sagepub.com
Nonsmall cell lung cancer (NSCLC) accounts for approximately 80%–85% of all lung cancer
patients. Gossypin, a flavonoid contained in Hibiscus vitifolius, has been reported as a …

BPA-induced prostatic hyperplasia in vitro is correlated with the unbalanced gene expression of AR and ER in the epithelium and stroma

K Wang, D Huang, P Zhou, X Su… - Toxicology and …, 2021 - journals.sagepub.com
As a typical environmental endocrine disruptor (EED), bisphenol A (BPA) can induce
pathological hyperplasia of the prostatic epithelium and stroma. This study concentrates …

Silencing E6/E7 Oncoproteins in SiHa Cells Treated with siRNAs and Oroxylum indicum Extracts Induced Apoptosis by Upregulating p53/pRb Pathways

NNT Sisin, AR Kong, HA Edinur, NIN Jamil… - Applied Biochemistry …, 2024 - Springer
E6 and E7 human papillomavirus (HPV) oncoproteins play a significant role in the malignant
transformation of infected cervical cancer cells via suppression of tumour suppressor …

Determination of anti-cancer effects of Nigella sativa seed oil on MCF7 breast and AGS gastric cancer cells

İ Çınar, B Gıdık, E Dirican - Molecular Biology Reports, 2024 - Springer
Background This study aimed to investigate the cytotoxic, apoptotic, invasion, metastasis,
and heat shock proteins (HSPs) effects of N. sativa oil on breast and gastric cancer cells …