Throughout the entirety of human history, bacterial pathogens have played an important role
and even shaped the fate of civilizations. The application of genomics within the last 27 …

Microbial cell-free DNA (mcfDNA) sequencing is an emerging infectious disease diagnostic
tool which enables unbiased pathogen detection and quantification from plasma. The Karius …

Welcome to the 29th edition of Nelson's Pediatric Antimicrobial Therapy, the third edition
written during the COVID-19 pandemic, which continues to significantly affect our lives and …

Abstract Background While Streptococcus pneumoniae (Spn) is the leading cause of
pediatric complicated community-acquired pneumonia (cCAP), it is infrequently recovered …

Sequencing of plasma microbial cell-free DNA (mcfDNA) has gained increased acceptance
as a valuable adjunct to standard-of-care testing for diagnosis of infections throughout the …

Background Paediatric community-acquired pneumonia (CAP) is a major public health
challenge in children, requiring accurate and timely diagnosis of causative pathogens for …

Pediatric pneumonia can be severe and result in empyema. Next-generation sequencing
(NGS) may broadly detect pathogens though, optimal timing and impact of sample type on …

Abstract Background The Karius Test (KT), a cell-free DNA metagenomic next-generation
sequencing assay, has potential to improve diagnostic evaluation of infectious diseases …

Background: We investigated the utilization of cell free microbial DNA (cfDNA) at a
Children's Hospital. Materials and Methods: cfDNA results were assessed regarding the …

Pediatric ear, nose, and throat (ENT) infections are common and vary from simple to life-
threatening cases, including complicated sinusitis, deep neck space abscesses, and …