Acute lymphoblastic leukemia (ALL) is the commonest childhood tumor and remains a
leading cause of cancer death in the young. In the last decade, microarray and sequencing …

Cancer is a complex disease resulting from the genetic and epigenetic disruption of normal
cells. The mechanistic understanding of the pathways involved in tumor transformation has …

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, accounting
for 25% of all childhood cancers. In the United States, approximately 3000 children aged 1 …

Background Although aberrant DNA methylation has been observed previously in acute
lymphoblastic leukemia (ALL), the patterns of differential methylation have not been …

Acute lymphoblastic leukaemia (ALL) is the commonest childhood cancer and an important
cause of morbidity from haematological malignancies in adults. In the past several years, we …

Myelodysplastic syndromes and chronic myelomonocytic leukemia (CMML) are
characterized by mutations in genes encoding epigenetic modifiers and aberrant DNA …

DNA methylation is tightly regulated during development and is stably maintained in healthy
cells. In contrast, cancer cells are commonly characterized by a global loss of DNA …

Although the cure rates of childhood acute lymphoblastic leukemia (ALL) have improved
dramatically in the past 40 years, not all children have benefited equally from this impressive …

DNMT3A, the gene encoding the de novo DNA methyltransferase 3A, is among the most
frequently mutated genes in hematologic malignancies. However, the mechanisms through …

Aberrant enhancer activation is a key mechanism driving oncogene expression in many
cancers. While much is known about the regulation of larger chromosome domains in …