• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

In eukaryotic cells AMP-activated protein kinase (AMPK) plays a major role in regulating
cellular energy balance. AMPK responds to changes in intracellular adenine nucleotide …

Kardiomiopatie definiuje się jako strukturalne oraz funkcjonalne nieprawidłowości mięśnia
komór, które nie wynikają z niedokrwienia na skutek choroby wieńcowej czy …

Cardiovascular remodelling in the conditioned athlete is frequently associated with
physiological ECG changes. Abnormalities, however, may be detected which represent …

New therapeutic approaches to counter the increasing prevalence of obesity and type 2
diabetes mellitus are in high demand. Deregulation of the phosphoinositide-3-kinase …

Advances in molecular genetics present new opportunities and challenges for cardiologists
who manage patients and families with cardiomyopathies. The aims of this position …

Wolff-Parkinson-White (WPW) electrocardiographic (ECG) pattern. 1 The terminology WPW
was first used to describe a “bundle-branch pattern” with a short PR interval in healthy young …

Background—Current information on the epidemiology and outcomes of hypertrophic
cardiomyopathy (HCM) in children is limited by disease diversity and small case series …

Opinion statement The treatment of mitochondrial disease varies considerably. Most experts
use a combination of vitamins, optimize patients' nutrition and general health, and prevent …

AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme that is expressed in most
mammalian tissues including cardiac muscle. Among the multiple biological processes …