Since the beginning of NMR spectroscopy, the observation of magnetically active nuclei with
low isotopic natural abundance as a tracer has been a noteworthy and exciting challenge for …

It is shown that very large differences exist in the internal distribution of natural deuterium
and the 2 H quantitative NMR method is proposed as an efficient tool for characterizing the …

This article is written as an overview of current marine biosynthetic knowledge and as an
extension of previous reviews in which the biosynthetic origins of marine natural products …

Incubations of isotopically pure [2-2H1](E, E)-farnesyl diphosphate with recombinant
patchoulol synthase (PTS) from Pogostemon cablin afforded a 65: 35 mixture of …

For several decades isotope labelling techniques have been the indispensable tools used to
unravel pathways of secondary product biosynthesis. NMR spectroscopy, together with …

The biosynthesis of penitrem A has been studied with both 13C-and 2H-labelled precursors,
viz.[1-13C]-,[2-13C]-,[1, 2-13C2]-, and [1-13C, 2-2H3]-acetate,[2-13C]-,[2, 3-13C2]-,[2-2H2] …

The high level incorporation of isotopically labelled sodium acetate and sodium propionate
into amphotericin B is reported. Double quantum filtered heteronuclear single quantum …

MY 104). During the course of biosynthetic studies4) of the main component, carbazomycin
B (I), we found that DL-[3-14C] tryptophan wasincorporated into I with the high efficiency of …

The isotope content and in particular the ratio of deuterium and hydrogen atoms in a given
molecular species, D/H, are not constant on Earth. On the basis of the overall molecular …

Natural abundance deuterium NMR spectroscopy is a powerful and convenient tool for the
estimation of deuterium kinetic isotope effects in organic reactions, obviating in many cases …