Segmentation of the paraxial mesoderm is a major event of vertebrate development that
establishes the metameric patterning of the body axis. This process involves the periodic …

Most cells in our body communicate during development and throughout life via Notch
receptors and their ligands. Notch receptors relay information from the cell surface to the …

In this essay I will sketch some ideas for how to think about models in biology. I will begin by
trying to dispel the myth that quantitative modeling is somehow foreign to biology. I will then …

Segmentation is a fundamental feature of the vertebrate body plan. This metameric
organization is first implemented by somitogenesis in the early embryo, when paired …

Many biological circuits comprise sets of protein variants that interact with one another in a
many-to-many, or promiscuous, fashion. These architectures can provide powerful …

Mutations of several genes cause incomplete penetrance and variable expressivity of
phenotypes, which are usually attributed to modifier genes or gene-environment …

There is now compelling evidence that many arthropods pattern their segments using a
clock-and-wavefront mechanism, analogous to that operating during vertebrate …

Vertebrate body segmentation is controlled by the segmentation clock, a molecular oscillator
involving transcriptional oscillations of cyclic genes in presomitic mesoderm cells. The rapid …

The metameric pattern of somites is created based on oscillatory expression of clock genes
in presomitic mesoderm. However, the mechanism for converting the dynamic oscillation to …

Body axis elongation and segmentation are major morphogenetic events that take place
concomitantly during vertebrate embryonic development. Establishment of the final body …