Nanotechnology and drug-release biomaterials have been thoroughly explored in the last
few years aiming to develop specialized clinical treatments. However, it is rare to find …

Animal models are fundamental to advance our knowledge of the underlying
pathophysiology of bone loss and to study pharmaceutical countermeasures against it. The …

Endochondral ossification (EO) is an essential biological process than underpins how
human bones develop, grow, and heal in the event of a fracture. So much is unknown about …

Rapid development of tissue engineering in recent years has increased the importance of
three-dimensional (3D) bioprinting technology as novel strategy for fabrication functional 3D …

Critical-sized diaphysis defects are complicated by inherent sub-optimal healing conditions.
The two-staged induced membrane technique has been used to treat these challenging …

Osteomyelitis is a challenging infectious disease affecting humans and animals. It is difficult
to diagnose because, in many cases, symptoms are non-specific and, for example in implant …

Bone contains a dense network of blood vessels that are essential to its homoeostasis,
endocrine function, mineral metabolism and regenerative functions. In addition, bone …

Nucleic acid nanostructures, derived from the assembly of nucleic acid building blocks (eg,
plasmids and oligonucleotides), are important intracellular carriers of therapeutic cargoes …

Abstract For Ti6Al4V orthopedic and spinal implants, osseointegration is often achieved
using complex porous geometries created via additive manufacturing (AM). While AM …

Osteotomy is a common step in oncological, reconstructive, and trauma surgery. Drilling and
elevated temperature during osteotomy produce thermal osteonecrosis. Heat and …