Antitubercular properties of thiazolidin-4-ones–A review
N Trotsko - European Journal of Medicinal Chemistry, 2021 - Elsevier
Thiazolidin-4-one scaffold has great potential for medicinal chemistry and is of interest to
scientists in view of wide spectrum of biological activity. This scaffold is often used for …
scientists in view of wide spectrum of biological activity. This scaffold is often used for …
“Big Three” infectious diseases: tuberculosis, malaria and HIV/AIDS
P Makam, R Matsa - Current Topics in Medicinal Chemistry, 2021 - ingentaconnect.com
Infectious diseases have been evolving and re-evolving over the ages and causing
immense misery to humans. Among them, some have been prevented and eradicated, but …
immense misery to humans. Among them, some have been prevented and eradicated, but …
Comprehensive review on mechanism of action, resistance and evolution of antimycobacterial drugs
Tuberculosis is one of the deadliest infectious diseases existing in the world since ancient
times and still possesses serious threat across the globe. Each year the number of cases …
times and still possesses serious threat across the globe. Each year the number of cases …
Synthetic molecules as DprE1 inhibitors: A patent review
Introduction In recent years, the advent of multidrug-resistant tuberculosis (MDR-TB), the
extensively-resistant TB (XDR-TB), and the total drug-resistant-TB (TDR-TB) have led the …
extensively-resistant TB (XDR-TB), and the total drug-resistant-TB (TDR-TB) have led the …
Promiscuous targets for antitubercular drug discovery: The paradigm of DprE1 and MmpL3
The development and spread of Mycobacterium tuberculosis multi-drug resistant strains still
represent a great global health threat, leading to an urgent need for novel anti-tuberculosis …
represent a great global health threat, leading to an urgent need for novel anti-tuberculosis …
DprE1 inhibitors: enduring aspirations for future antituberculosis drug discovery
DprE1 is a crucial enzyme involved in the cell wall synthesis of Mycobacterium tuberculosis
and a promising target for antituberculosis drug development. However, its unique structural …
and a promising target for antituberculosis drug development. However, its unique structural …
[HTML][HTML] An insight into the discovery, clinical studies, compositions, and patents of macozinone: A drug targeting the DprE1 enzyme of Mycobacterium tuberculosis
Abstract Decaprenyl-phosphoryl-ribose 2′-epimerase (DprE1) inhibitors are an innovative
and futuristic orally active group of antituberculosis agents. A few DprE1 inhibitors are in the …
and futuristic orally active group of antituberculosis agents. A few DprE1 inhibitors are in the …
MmpL3 inhibitors as antituberculosis drugs
The mycobacterial membrane protein Large 3 (MmpL3) is an inner membrane protein that
transports trehalose-monomycolates, precursors for trehalose-dimycolates and mycolic …
transports trehalose-monomycolates, precursors for trehalose-dimycolates and mycolic …
Natural products and their analogues acting against Mycobacterium tuberculosis: A recent update
G Kumar - Drug Development Research, 2023 - Wiley Online Library
Tuberculosis (TB) remains one of the deadliest infectious diseases caused by
Mycobacterium tuberculosis (M. tb). It is responsible for significant causes of mortality and …
Mycobacterium tuberculosis (M. tb). It is responsible for significant causes of mortality and …
Mycobacterium tuberculosis DprE1 Inhibitor OPC-167832 Is Active against Mycobacterium abscessus In Vitro
JP Sarathy, MD Zimmerman… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
The antituberculosis candidate OPC-167832, an inhibitor of DprE1, was active against
Mycobacterium abscessus. Resistance mapped to M. abscessus dprE1, suggesting target …
Mycobacterium abscessus. Resistance mapped to M. abscessus dprE1, suggesting target …