The neuroscience of sugars in taste, gut-reward, feeding circuits, and obesity

R Gutierrez, E Fonseca, SA Simon - Cellular and Molecular Life Sciences, 2020 - Springer
Throughout the animal kingdom sucrose is one of the most palatable and preferred tastants.
From an evolutionary perspective, this is not surprising as it is a primary source of energy …

Recognizing taste: coding patterns along the neural axis in mammals

K Ohla, R Yoshida, SD Roper, PM Di Lorenzo… - Chemical …, 2019 - academic.oup.com
The gustatory system encodes information about chemical identity, nutritional value, and
concentration of sensory stimuli before transmitting the signal from taste buds to central …

Breadth of tuning in taste afferent neurons varies with stimulus strength

A Wu, G Dvoryanchikov, E Pereira, N Chaudhari… - Nature …, 2015 - nature.com
Gustatory stimuli are detected by taste buds and transmitted to the hindbrain via sensory
afferent neurons. Whether each taste quality (sweet, bitter and so on) is encoded by …

An open-source platform for head-fixed operant and consummatory behavior

A Gordon-Fennell, JM Barbakh, MKT Utley, S Singh… - Elife, 2023 - elifesciences.org
Head-fixed behavioral experiments in rodents permit unparalleled experimental control,
precise measurement of behavior, and concurrent modulation and measurement of neural …

The insula and taste learning

A Yiannakas, K Rosenblum - Frontiers in Molecular Neuroscience, 2017 - frontiersin.org
The sense of taste is a key component of the sensory machinery, enabling the evaluation of
both the safety as well as forming associations regarding the nutritional value of ingestible …

Single and population coding of taste in the gustatory cortex of awake mice

D Levitan, JY Lin, J Wachutka… - Journal of …, 2019 - journals.physiology.org
Electrophysiological analysis has revealed much about the broad coding and neural
ensemble dynamics that characterize gustatory cortical (GC) taste processing in awake rats …

The behavioral relevance of cortical neural ensemble responses emerges suddenly

BF Sadacca, N Mukherjee, T Vladusich… - Journal of …, 2016 - Soc Neuroscience
Whereas many laboratory-studied decisions involve a highly trained animal identifying an
ambiguous stimulus, many naturalistic decisions do not. Consumption decisions, for …

Sucrose intensity coding and decision-making in rat gustatory cortices

E Fonseca, V de Lafuente, SA Simon, R Gutierrez - Elife, 2018 - elifesciences.org
Sucrose's sweet intensity is one attribute contributing to the overconsumption of high-energy
palatable foods. However, it is not known how sucrose intensity is encoded and used to …

Activation of glutamatergic fibers in the anterior NAc shell modulates reward activity in the aNAcSh, the lateral hypothalamus, and medial prefrontal cortex and …

L Prado, J Luis-Islas, OI Sandoval, L Puron… - Journal of …, 2016 - Soc Neuroscience
Although the release of mesoaccumbal dopamine is certainly involved in rewarding
responses, recent studies point to the importance of the interaction between it and …

Tesofensine, a novel antiobesity drug, silences GABAergic hypothalamic neurons

CI Perez, J Luis-Islas, A Lopez, X Diaz, O Molina… - PLoS …, 2024 - journals.plos.org
Obesity is a major global health epidemic that has adverse effects on both the people
affected as well as the cost to society. Several anti-obesity drugs that target GLP-1 receptors …