The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …

Neurons have more extended and complex shapes than other cells and consequently face a
greater challenge in distributing and maintaining mitochondria throughout their arbors …

Local translation meets protein turnover and plasticity demands at synapses, however, the
location of its energy supply is unknown. We found that local translation in neurons is …

Mitochondria play many important biological roles, including ATP production, lipid
biogenesis, ROS regulation, and calcium clearance. In neurons, the mitochondrion is an …

Mitochondria are key cellular power plants essential for neuronal growth, survival, function,
and regeneration after injury. Given their unique morphological features, neurons face …

Mitochondria are the main suppliers of neuronal adenosine triphosphate and play a critical
role in brain energy metabolism. Mitochondria also serve as Ca2+ sinks and anabolic …

Synapses are pivotal sites of plasticity and memory formation. Consequently, synapses are
energy consumption hotspots susceptible to dysfunction when their energy supplies are …

Actin is a versatile and ubiquitous cytoskeletal protein that plays a major role in both the
establishment and the maintenance of neuronal polarity. For a long time, the most prominent …

Kymographs are graphical representations of spatial position over time, which are often
used in biology to visualise the motion of fluorescent particles, molecules, vesicles, or …

Efficient neuronal function depends on the continued modulation of the local neuronal
proteome. Local protein synthesis plays a central role in tuning the neuronal proteome at …