Since Hedin's characterization of trypsin and antitrypsin in 1906,(1) arguably the first
account of a regulatory protein–protein interaction (PPI), contemporary understanding of …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

The linear or branched allyl moieties on aromatic rings are well-known as ubiquitous
structural motifs found in a range of natural products and medicinally relevant molecules …

Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disease of
adults which preferentially attacks the neuromotor system. Riluzole has been used as the …

The endothelium controls vascular tone not only by releasing NO and prostacyclin, but also
by other pathways causing hyperpolarization of the underlying smooth muscle cells. This …

The relationship between cerebellar dysfunction, motor symptoms, and neuronal loss in the
inherited ataxias, including the polyglutamine disease spinocerebellar ataxia type 3 (SCA3) …

Potassium channels belong to the largest and the most diverse super-families of ion
channels. Among them, Ca 2+-activated K+ channels (KCa) comprise many members …

Aryl trifluoromethoxylation by a two‐step sequence of O‐trifluoromethylation of N‐aryl‐N‐
hydroxylamine derivatives and intramolecular OCF3 migration is presented. This protocol …

The Ca2+-activated K+ channel KCa3. 1 regulates membrane potential and calcium
signaling in erythrocytes, activated T and B cells, macrophages, microglia, vascular …

The present review first summarizes the complex chain of events, in endothelial and
vascular smooth muscle cells, that leads to endothelium-dependent relaxations …