Alzheimer's disease (AD) is the leading cause of dementia, presenting a significant unmet
medical need worldwide. The pathogenesis of AD involves various pathophysiological …

Alzheimer disease (AD) accounts for 60–70% of dementia cases. Given the seriousness of
the disease and continual increase in patient numbers, developing effective therapies to …

The so-called amyloid hypothesis, that the accumulation and deposition of oligomeric or
fibrillar amyloid β (Aβ) peptide is the primary cause of Alzheimer's disease (AD), has been …

Synaptic loss is the best correlate of cognitive deficits in Alzheimer's disease (AD). Extensive
experimental evidence also indicates alterations of synaptic properties at the early stages of …

In Alzheimer's disease (AD), the distribution of the amyloid precursor protein (APP) and its
fragments other than amyloid beta, has not been fully characterized. Here, we investigate …

Alzheimer's disease (AD) is the leading cause of dementia and the most common
neurodegenerative disorder. AD is mostly a sporadic disorder and its main risk factor is age …

A large body of evidences indicates that axonal transport (AT) defects play an important role
in the pathogenesis of Alzheimer'disease (AD). AT, a critical cellular process for the …

Neurotrophins are a family of proteins that are important for neuronal development, neuronal
survival and neuronal functions. Neurotrophins exert their role by binding to their receptors …

Emerging evidence suggests that the dysregulation of fast axonal transport (FAT) plays a
crucial role in several neurodegenerative disorders. Some of these diseases are caused by …

Axonal transport is indispensable for the distribution of vesicles, organelles, messenger
RNAs (mRNAs), and signaling molecules along the axon. This process is mediated by …