Osteocalcin (Ocn), which is specifically produced by osteoblasts, and is the most abundant
non-collagenous protein in bone, was demonstrated to inhibit bone formation and function …

In the last two decades we have witnessed sizable progress in defining the role of
gastrointestinal signals in the control of glucose and energy homeostasis. Specifically, the …

The strength of bone depends on bone quantity and quality. Osteocalcin (Ocn) is the most
abundant noncollagenous protein in bone and is produced by osteoblasts. It has been …

In 2005, the International Union of Basic and Clinical Pharmacology Committee on Receptor
Nomenclature and Drug Classification (NC-IUPHAR) published a catalog of all of the human …

The skeleton has recently emerged as an endocrine organ implicated in the regulation of
glucose and energy metabolism. This function of bone is mediated, at least in part, by …

L-arginine, an endogenous amino acid, is a safe substance that can be found in food. The
compound is involved in synthesis of various products responsible for regulatory functions in …

Background Osteocalcin is the most abundant non-collagenous protein in bone and is
specifically expressed in osteoblasts. Previous studies using osteocalcin-deficient (Ocn–/–) …

G-protein coupled receptors (GPCRs) regulate hormone secretion from islets of Langerhans,
and recently developed therapies for type-2 diabetes target islet GLP-1 receptors. However …

G protein–coupled receptors (GPCRs) continue to be important discovery targets for the
treatment of type 2 diabetes mellitus (T2DM). Many GPCRs are directly involved in the …

An increasing amount of data indicate that osteocalcin is an endocrine hormone which
regulates energy metabolism, male fertility and brain development. However, the detailed …