The role of Caenorhabditis elegans in the discovery of natural products for healthy aging

B Kirchweger, J Zwirchmayr, U Grienke… - Natural Product …, 2023 - pubs.rsc.org
Covering: 2012 to 2023 The human population is aging. Thus, the greatest risk factor for
numerous diseases, such as diabetes, cancer and neurodegenerative disorders, is …

Cannabinoids and healthy ageing: the potential for extending healthspan and lifespan in preclinical models with an emphasis on Caenorhabditis elegans

Z Wang, JC Arnold - GeroScience, 2024 - Springer
There is a significant global upsurge in the number and proportion of older persons in the
population. With this comes an increasing prevalence of age-related conditions which pose …

The Antioxidant and Neuroprotective Potential of Leaves and Inflorescences Extracts of Selected Hemp Varieties Obtained with scCO2

A Stasiłowicz-Krzemień, S Sip, P Szulc, J Walkowiak… - Antioxidants, 2023 - mdpi.com
Cannabis sativa, a versatile plant with numerous varieties, holds promising potential for a
wide range of biological activity. As raw materials for research, we chose leaves and …

Cannabidiol Recovers Dopaminergic Neuronal Damage Induced by Reserpine or α-synuclein in Caenorhabditis elegans

E da Cruz Guedes, AG Erustes, AHFF Leão… - Neurochemical …, 2023 - Springer
Progressive neurodegenerative disorders such as Parkinson Disease (PD) lack curative or
long-term treatments. At the same time, the increase of the worldwide elderly population …

Δ8-THC Induces Up-Regulation of Glutamatergic Pathway Genes in Differentiated SH-SY5Y: A Transcriptomic Study

I Anchesi, G Schepici, L Chiricosta… - International Journal of …, 2023 - mdpi.com
Cannabinoids, natural or synthetic, have antidepressant, anxiolytic, anticonvulsant, and anti-
psychotic properties. Cannabidiol (CBD) and delta-9-tetrahydrocannabinol (Δ9-THC) are the …

[HTML][HTML] Polyphenol-rich fermented hempseed ethanol extracts improve obesity, oxidative stress, and neural health in high-glucose diet-induced Caenorhabditis …

SO Aloo, K Barathikannan, DH Oh - Food Chemistry: X, 2024 - Elsevier
Whole hempseed (WHS), fermented whole hempseed (FWHS), dehulled hempseed (DHS),
and fermented dehulled hempseed (FDHS) ethanol extracts were tested for their toxicity and …

Early-life caffeine exposure induces morphological changes and altered physiology in Caenorhabditis elegans

L Kuo-Esser, R Chen, K Lawson, K Kuchinski… - Biochemical and …, 2024 - Elsevier
Caffeine, a widely consumed stimulant, is known for its effects on alertness and fatigue
reduction by blockade of adenosine receptors. While it holds therapeutic potential, its …

Characterization of Phenolic Compounds in Extra Virgin Olive Oil from Granada (Spain) and Evaluation of Its Neuroprotective Action

MA López-Bascón, I Moscoso-Ruiz… - International Journal of …, 2024 - mdpi.com
The olive oil sector is a fundamental food in the Mediterranean diet. It has been
demonstrated that the consumption of extra virgin olive oil (EVOO) with a high content of …

Cannabis sativa-based oils against aluminum-induced neurotoxicity

C Alves, WA Tamagno, AP Vanin, A Pompermaier… - Scientific Reports, 2023 - nature.com
The use of terpenoid compounds in different neural-related conditions is becoming useful for
several illnesses. Another possible activity of these compounds is the reduction of nervous …

Synthesis and Physicochemical Stability of a Copaiba Balsam Oil (Copaifera sp.) Nanoemulsion and Prospecting of Toxicological Effects on the Nematode …

IC Bezerra, ERS Santos, JSR Bisneto, PP Perruci… - ACS …, 2024 - ACS Publications
Nanoemulsions are dispersions of oil-in-water (O/W) and water-in-oil (W/O) immiscible
liquids. Thus, our main goal was to formulate a nanoemulsion with low surfactant …