The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …

Metabolic flexibility is the ability to respond or adapt to conditional changes in metabolic
demand. This broad concept has been propagated to explain insulin resistance and …

The presence of lactate in human tumours has been long neglected, confined to the role of a
waste product derived from glycolysis and as a biomarker of malignancy. More recently …

Simple Summary Reprogramming of glucose metabolism is a hallmark of cancer and can be
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …

Melanomas are metabolically heterogeneous, and they are able to adapt in order to utilize a
variety of fuels that facilitate tumor progression and metastasis. The significance of …

Recent evidence highlights that the cancer cell energy requirements vary greatly from
normal cells and that cancer cells exhibit different metabolic phenotypes with variable …

Currently, there is increasing evidence linking diabetes mellitus (especially type 2 diabetes
mellitus) with carcinogenesis through various biological processes, such as fat-induced …

Simple Summary In the last two decades, the antidiabetic drugs, biguanides, have received
considerable interest owing to their presumed antitumor properties. A critical issue that has …

Digestive system cancer tumors are one of the major causes of cancer-related fatalities; the
vast majority of them are colorectal or gastric malignancies. Epidemiological evidence …

Altered metabolism is a hallmark of cancers, including shifting oxidative phosphorylation to
glycolysis and up‐regulating glutaminolysis to divert carbon sources into biosynthetic …