Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among
eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons …

The presence of atypical cytoskeletal dynamics, structures, and associated morphologies is
a common theme uniting numerous diseases and developmental disorders. In particular …

Cofilactin rod pathology, which can initiate synapse loss, has been extensively studied in
rodent neurons, hippocampal slices, and in vivo mouse models of human …

The blood-brain barrier (BBB) regulates the exchange of metabolites and cells between the
blood and brain, and maintains central nervous system homeostasis. Various factors affect …

The actin cytoskeleton is a biosensor of cellular stress and a potential prognosticator of
human disease. In particular, aberrant cytoskeletal structures such as stress granules …

BAR (Bin, Amphiphysin, and Rvs) protein domains are responsible for the generation of
membrane curvature and represent a critical mechanical component of cellular functions …

Proteins involved in neurodegeneration can be coupled with optogenetic reagents to create
rapid and sensitive reporters to provide insight into the biochemical processes that mediate …

Actin-Cofilin rods are an important marker of neurodegenerative disease and are commonly
observed in the neurons of patients with Alzheimer's disease. The goal of this research is to …