Alzheimer's disease: experimental models and reality

E Drummond, T Wisniewski - Acta neuropathologica, 2017 - Springer
Experimental models of Alzheimer's disease (AD) are critical to gaining a better
understanding of pathogenesis and to assess the potential of novel therapeutic approaches …

Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery

UB Pandey, CD Nichols, EL Barker - Pharmacological reviews, 2011 - Elsevier
The common fruit fly, Drosophila melanogaster, is a well studied and highly tractable genetic
model organism for understanding molecular mechanisms of human diseases. Many basic …

Tau protein aggregation in Alzheimer's disease: An attractive target for the development of novel therapeutic agents

M Jouanne, S Rault, AS Voisin-Chiret - European journal of medicinal …, 2017 - Elsevier
Alzheimer's Disease (AD) is a neurodegenerative brain disorder in which many biological
dysfunctions are involved. Among them, two main types of lesions were discovered and …

The developing utility of zebrafish models of neurological and neuropsychiatric disorders: A critical review

BD Fontana, NJ Mezzomo, AV Kalueff… - Experimental …, 2018 - Elsevier
Zebrafish (Danio rerio) have become a powerful tool in neuroscience research due to their
genetic tractability, molecular/physiological conservation, small body size, ease of …

Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG)

NA Singh, AKA Mandal, ZA Khan - Nutrition journal, 2015 - Springer
Neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease
(PD) enforce an overwhelming social and economic burden on society. They are primarily …

Zebrafish: an emerging real-time model system to study Alzheimer's disease and neurospecific drug discovery

S Saleem, RR Kannan - Cell death discovery, 2018 - nature.com
Zebrafish (Danio rerio) is emerging as an increasingly successful model for translational
research on human neurological disorders. In this review, we appraise the high degree of …

[HTML][HTML] Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

CA Lasagna-Reeves, DL Castillo-Carranza… - The FASEB …, 2012 - ncbi.nlm.nih.gov
Neurofibrillary tangles (NFTs) are a pathological hallmark of Alzheimer's disease (AD);
however, the relationship between NFTs and disease progression remains controversial …

TNF induces pathogenic programmed macrophage necrosis in tuberculosis through a mitochondrial-lysosomal-endoplasmic reticulum circuit

FJ Roca, LJ Whitworth, S Redmond, AA Jones… - Cell, 2019 - cell.com
Necrosis of infected macrophages constitutes a critical pathogenetic event in tuberculosis by
releasing mycobacteria into the growth-permissive extracellular environment. In zebrafish …

Advances of zebrafish in neurodegenerative disease: from models to drug discovery

X Wang, JB Zhang, KJ He, F Wang… - Frontiers in Pharmacology, 2021 - frontiersin.org
Neurodegenerative disease (NDD), including Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, are characterized by the progressive loss of neurons which …

Zebrafish as a model organism for neurodegenerative disease

K Chia, A Klingseisen, D Sieger… - Frontiers in molecular …, 2022 - frontiersin.org
The zebrafish is increasingly recognized as a model organism for translational research into
human neuropathology. The zebrafish brain exhibits fundamental resemblance with human …