Chronic kidney disease (CKD) is a common and progressive disease that has become a
major public health problem on a global scale. Renal fibrosis is a common feature in the …

Astragalus is a popular Materia Medica in China, and it could be applied in the treatment of
various diseases. It contains a variety of chemically active ingredients, such as saponins …

Hypoxia-inducible factor 1 (HIF-1) plays a pivotal role in tumor adaptation to
microenvironmental hypoxia, and it also exerts important roles in angiogenesis and tumor …

Previously, we reported that the secreted lysyl oxidase like 2 (LOXL2) from hepatocellular
carcinoma (HCC) cells under higher stiffness stimulation contributed to the formation of lung …

Abstract Ethnopharmacological relevance Danggui (Chinese Angelica root; Dong quai;
Angelica sinensis (Oliv.) Diels.) is a traditional Chinese herbal remedy with a long history of …

Ethnopharmacological relevance Herb compatibility is one of the most important
characteristics of traditional Chinese medicine (TCM). Rather than being used singly …

BACKGROUND AND PURPOSE Ligustilide, the main lipophilic component of Danggui, has
been reported to protect the brain against ischaemic injury. However, the mechanisms are …

Abstract Ethnopharmacological relevance Danggui Buxue Decoction (DBD) is a classic
prescription of traditional Chinese medicine that is mainly used for treating clinical anemia …

Radix Astragali (RA) is commonly used as a health food supplement to reinforce the body
vital energy. Flavonoids, including formononetin, ononin, calycosin, and calycosin-7-O-β-d …

Hypoxic exposure makes plateau migrators susceptible to high altitude polycythemia
(HAPC). Astragalus membranaceus (AM) is an edible and medicinal plant with remarkable …