Recent advances of injectable hydrogels for drug delivery and tissue engineering applications

Y Sun, D Nan, H Jin, X Qu - Polymer Testing, 2020 - Elsevier
Injectable hydrogel is a kind of in situ gelling system but has its specificity on the process
procedure, which requires a better control of gelation kinetics. Hydrogels with injectability …

Hydrogel biomaterials for application in ocular drug delivery

CR Lynch, PPD Kondiah, YE Choonara… - … in bioengineering and …, 2020 - frontiersin.org
There are many challenges involved in ocular drug delivery. These are a result of the many
tissue barriers and defense mechanisms that are present with the eye; such as the cornea …

[HTML][HTML] Synthesis and evaluation of alginate, gelatin, and hyaluronic acid hybrid hydrogels for tissue engineering applications

A Serafin, M Culebras, MN Collins - International journal of biological …, 2023 - Elsevier
Tissue engineering (TE) has been proposed extensively as a potential solution to the
worldwide shortages of donor organs needed for transplantation. Over the years, numerous …

[HTML][HTML] Modified hyaluronic acid hydrogels with chemical groups that facilitate adhesion to host tissues enhance cartilage regeneration

J Chen, J Yang, L Wang, X Zhang, BC Heng… - Bioactive Materials, 2021 - Elsevier
Stable integration of hydrogel implants with host tissues is of critical importance to cartilage
tissue engineering. Designing and fabricating hydrogels with high adhesive strength …

Polysaccharide-based hydrogels for medical devices, implants and tissue engineering: A review

D Sanjanwala, V Londhe, R Trivedi, S Bonde… - International Journal of …, 2024 - Elsevier
Hydrogels are highly biocompatible biomaterials composed of crosslinked three-
dimensional networks of hydrophilic polymers. Owing to their natural origin, polysaccharide …

Hydrogels in ophthalmic applications

S Kirchhof, AM Goepferich, FP Brandl - European Journal of Pharmaceutics …, 2015 - Elsevier
More and more people worldwide are affected by severe eye diseases eventually leading to
visual impairment or blindness. In most cases, the treatment involves the application of …

Applications of hyaluronic acid in ophthalmology and contact lenses

WH Chang, PY Liu, MH Lin, CJ Lu, HY Chou, CY Nian… - Molecules, 2021 - mdpi.com
Hyaluronic acid (HA) is a glycosaminoglycan that was first isolated and identified from the
vitreous body of a bull's eye. HA is ubiquitous in the soft connective tissues of animals and …

Characterization of silk-hyaluronic acid composite hydrogels towards vitreous humor substitutes

NR Raia, D Jia, CE Ghezzi, M Muthukumar, DL Kaplan - Biomaterials, 2020 - Elsevier
Multiple ophthalmic pathologies, such as retinal detachment and diabetic retinopathy,
require the removal and replacement of the vitreous humor. Clinical tamponades such as …

[HTML][HTML] 3D culture of human pluripotent stem cells in RGD-alginate hydrogel improves retinal tissue development

NC Hunt, D Hallam, A Karimi, CB Mellough, J Chen… - Acta biomaterialia, 2017 - Elsevier
No treatments exist to effectively treat many retinal diseases. Retinal pigmented epithelium
(RPE) and neural retina can be generated from human embryonic stem cells/induced …

Polymeric hydrogels as a vitreous replacement strategy in the eye

Q Lin, JYC Lim, K Xue, X Su, XJ Loh - Biomaterials, 2021 - Elsevier
Vitreous endo-tamponades are commonly used in the treatment of retinal detachments and
tears. They function by providing a tamponading force to support the retina after retina …