Functions and consequences of AID/APOBEC-mediated DNA and RNA deamination
R Pecori, S Di Giorgio, J Paulo Lorenzo… - Nature Reviews …, 2022 - nature.com
The AID/APOBEC polynucleotide cytidine deaminases have historically been classified as
either DNA mutators or RNA editors based on their first identified nucleic acid substrate …
either DNA mutators or RNA editors based on their first identified nucleic acid substrate …
Mechanisms of viral mutation
R Sanjuán, P Domingo-Calap - Cellular and molecular life sciences, 2016 - Springer
The remarkable capacity of some viruses to adapt to new hosts and environments is highly
dependent on their ability to generate de novo diversity in a short period of time. Rates of …
dependent on their ability to generate de novo diversity in a short period of time. Rates of …
Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA
Clustered somatic mutations are common in cancer genomes and previous analyses reveal
several types of clustered single-base substitutions, which include doublet-and multi-base …
several types of clustered single-base substitutions, which include doublet-and multi-base …
No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2
COVID-19 is caused by the coronavirus SARS-CoV-2, which jumped into the human
population in late 2019 from a currently uncharacterised animal reservoir. Due to this recent …
population in late 2019 from a currently uncharacterised animal reservoir. Due to this recent …
Evidence for host-dependent RNA editing in the transcriptome of SARS-CoV-2
The COVID-19 outbreak has become a global health risk, and understanding the response
of the host to the SARS-CoV-2 virus will help to combat the disease. RNA editing by host …
of the host to the SARS-CoV-2 virus will help to combat the disease. RNA editing by host …
Identification of genetically intact HIV-1 proviruses in specific CD4+ T cells from effectively treated participants
Latent replication-competent HIV-1 persists in individuals on long-term antiretroviral therapy
(ART). We developed the Full-Length Individual Proviral Sequencing (FLIPS) assay to …
(ART). We developed the Full-Length Individual Proviral Sequencing (FLIPS) assay to …
Rampant C→ U hypermutation in the genomes of SARS-CoV-2 and other coronaviruses: causes and consequences for their short-and long-term evolutionary …
P Simmonds - Msphere, 2020 - Am Soc Microbiol
The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
motivated an intensive analysis of its molecular epidemiology following its worldwide …
motivated an intensive analysis of its molecular epidemiology following its worldwide …
Addressing the benefits of inhibiting APOBEC3-dependent mutagenesis in cancer
Mutational signatures associated with apolipoprotein B mRNA-editing enzyme catalytic
polypeptide-like (APOBEC) 3 cytosine deaminase activity have been found in over half of …
polypeptide-like (APOBEC) 3 cytosine deaminase activity have been found in over half of …
Extracellular vesicles and viruses: Are they close relatives?
E Nolte-'t Hoen, T Cremer, RC Gallo… - Proceedings of the …, 2016 - National Acad Sciences
Extracellular vesicles (EVs) released by various cells are small phospholipid membrane-
enclosed entities that can carry miRNA. They are now central to research in many fields of …
enclosed entities that can carry miRNA. They are now central to research in many fields of …
The APOBEC protein family: united by structure, divergent in function
JD Salter, RP Bennett, HC Smith - Trends in biochemical sciences, 2016 - cell.com
The APOBEC (apolipoprotein B mRNA editing catalytic polypeptide-like) family of proteins
have diverse and important functions in human health and disease. These proteins have an …
have diverse and important functions in human health and disease. These proteins have an …