Herb-drug interactions and mechanistic and clinical considerations
XW Chen, KB Sneed, SY Pan, C Cao… - Current drug …, 2012 - ingentaconnect.com
Herbal medicines are often used in combination with conventional drugs, and this may give
rise to the potential of harmful herb-drug interactions. This paper updates our knowledge on …
rise to the potential of harmful herb-drug interactions. This paper updates our knowledge on …
The effects of obesity on drug pharmacokinetics in humans
GA Morrish, MP Pai, B Green - Expert opinion on drug metabolism …, 2011 - Taylor & Francis
Introduction: The prevalence of obesity and associated co-morbid conditions is increasing
globally. Physiological changes accompanying obesity are likely to result in altered drug …
globally. Physiological changes accompanying obesity are likely to result in altered drug …
Evaluation of potential herbal-drug interactions of a standardized propolis extract (EPP-AF®) using an in vivo cocktail approach
DAC Cusinato, EZ Martinez, MTC Cintra… - Journal of …, 2019 - Elsevier
Ethnopharmacological relevance Propolis has been employed extensively in many cultures
since ancient times as antiseptic, wound healing, anti-pyretic and others due to its biological …
since ancient times as antiseptic, wound healing, anti-pyretic and others due to its biological …
The basel cocktail for simultaneous phenotyping of human cytochrome P450 isoforms in plasma, saliva and dried blood spots
M Donzelli, A Derungs, MG Serratore, C Noppen… - Clinical …, 2014 - Springer
Abstract Background and Objective Phenotyping cocktails use a combination of cytochrome
P450 (CYP)-specific probe drugs to simultaneously assess the activity of different CYP …
P450 (CYP)-specific probe drugs to simultaneously assess the activity of different CYP …
[HTML][HTML] Human induced pluripotent stem cells in hepatology: beyond the proof of concept
S Gerbal-Chaloin, N Funakoshi, A Caillaud… - The American journal of …, 2014 - Elsevier
The discovery of the wide plasticity of most cell types means that it is now possible to
produce virtually any cell type in vitro. This concept, developed because of the possibility of …
produce virtually any cell type in vitro. This concept, developed because of the possibility of …
Simultaneous LC–MS/MS quantification of P-glycoprotein and cytochrome P450 probe substrates and their metabolites in DBS and plasma
M Bosilkovska, J Déglon, C Samer, B Walder… - Bioanalysis, 2014 - Taylor & Francis
Background: An LC–MS/MS method has been developed for the simultaneous quantification
of P-glycoprotein (P-gp) and cytochrome P450 (CYP) probe substrates and their Phase I …
of P-glycoprotein (P-gp) and cytochrome P450 (CYP) probe substrates and their Phase I …
To genotype or phenotype for personalized medicine? CYP450 drug metabolizing enzyme genotype–phenotype concordance and discordance in the Ecuadorian …
F De Andrés, S Terán, F Hernández… - Omics: a journal of …, 2016 - liebertpub.com
Genetic variations within the cytochrome P450 (CYP450) superfamily of drug metabolizing
enzymes confer substantial person-to-person and between-population differences in …
enzymes confer substantial person-to-person and between-population differences in …
A cocktail of metabolic probes demonstrates the relevance of primary human hepatocyte cultures in a microfluidic biochip for pharmaceutical drug screening
JM Prot, O Videau, C Brochot, C Legallais… - International journal of …, 2011 - Elsevier
In this paper, we compare the biotransformation capacities of cryopreserved primary human
hepatocytes cultivated in a liver microfluidic biochip and in plates. The hepatocytes were …
hepatocytes cultivated in a liver microfluidic biochip and in plates. The hepatocytes were …
Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips
R Baudoin, JM Prot, G Nicolas, J Brocheton… - Xenobiotica, 2013 - Taylor & Francis
We present characterization of the metabolic performance of human cryopreserved
hepatocytes cultivated in a platform of parallelized microfluidic biochips. The RTqPCR …
hepatocytes cultivated in a platform of parallelized microfluidic biochips. The RTqPCR …
Critical assessment of phenotyping cocktails for clinical use in an African context
M Leuschner, AD Cromarty - Journal of Personalized Medicine, 2023 - mdpi.com
Interethnic and interindividual variability in in vivo cytochrome P450 (CYP450)-dependent
metabolism and altered drug absorption via expressed transport channels such as P …
metabolism and altered drug absorption via expressed transport channels such as P …