Anti-diabetic drugs recent approaches and advancements
J Dowarah, VP Singh - Bioorganic & medicinal chemistry, 2020 - Elsevier
Diabetes is one of the major diseases worldwide and is the third leading cause of death in
the United States. Anti-diabetic drugs are used in the treatment of diabetes mellitus to control …
the United States. Anti-diabetic drugs are used in the treatment of diabetes mellitus to control …
Design and synthesis of thiazolidine-2, 4-diones hybrids with 1, 2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: In-vitro anticancer evaluation …
Abstract A thiazolidine-2, 4-dione nucleus was molecularly hybridised with the effective
antitumor moieties; 2-oxo-1, 2-dihydroquinoline and 2-oxoindoline to obtain new hybrids …
antitumor moieties; 2-oxo-1, 2-dihydroquinoline and 2-oxoindoline to obtain new hybrids …
New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: Design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in …
A new series of benzoxazole derivatives were designed and synthesised to have the main
essential pharmacophoric features of VEGFR-2 inhibitors. Cytotoxic activities were …
essential pharmacophoric features of VEGFR-2 inhibitors. Cytotoxic activities were …
Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFR WT and EGFR T790M
A new series of pyrimidine-5-carbonitrile derivatives has been designed as ATP mimicking
tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR). These compounds …
tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR). These compounds …
Discovery of thieno [2, 3-d] pyrimidine-based derivatives as potent VEGFR-2 kinase inhibitors and anti-cancer agents
SA El-Metwally, MM Abou-El-Regal, IH Eissa… - Bioorganic …, 2021 - Elsevier
Vascular endothelial growth factor-2 (VEGFR-2) is considered one of the most important
factors in tumor angiogenesis, and consequently a number of anticancer therapeutics have …
factors in tumor angiogenesis, and consequently a number of anticancer therapeutics have …
A multistage in silico study of natural potential inhibitors targeting SARS-CoV-2 main protease
Among a group of 310 natural antiviral natural metabolites, our team identified three
compounds as the most potent natural inhibitors against the SARS-CoV-2 main protease …
compounds as the most potent natural inhibitors against the SARS-CoV-2 main protease …
New quinoxaline-2 (1 H)-ones as potential VEGFR-2 inhibitors: Design, synthesis, molecular docking, ADMET profile and anti-proliferative evaluations
Eleven new quinoxaline derivatives were designed and synthesized as modified VEGFR-2
inhibitors of our previous work. The synthesized compounds were tested against three …
inhibitors of our previous work. The synthesized compounds were tested against three …
New quinoxaline-based VEGFR-2 inhibitors: Design, synthesis, and antiproliferative evaluation with in silico docking, ADMET, toxicity, and DFT studies
A new series of 3-methylquinoxaline-based derivatives having the same essential
pharmacophoric features as VEGFR-2 inhibitors have been synthesized and evaluated for …
pharmacophoric features as VEGFR-2 inhibitors have been synthesized and evaluated for …
Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico, In Vitro, and SAR …
C Ma, MS Taghour, A Belal, ABM Mehany… - Frontiers in …, 2021 - frontiersin.org
Guided by the structural optimization principle and the promising anticancer effect of the
quinoxaline nucleus, a new series of novel HDAC inhibitors were designed and …
quinoxaline nucleus, a new series of novel HDAC inhibitors were designed and …
Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and in vivo …
MM Khalifa, AA Al-Karmalawy, EB Elkaeed… - Journal of Enzyme …, 2022 - Taylor & Francis
This research presents the design and synthesis of a novel series of phthalazine derivatives
as Topo II inhibitors, DNA intercalators, and cytotoxic agents. In vitro testing of the new …
as Topo II inhibitors, DNA intercalators, and cytotoxic agents. In vitro testing of the new …