Cognitive deficits are a common comorbidity with neurological disorders and normal aging.
Inflammation is associated with multiple diseases including classical neurodegenerative …

The patterns of synaptic connectivity and physiological properties of diverse neuron types
are shaped by distinct gene sets. Our study demonstrates that, in the mouse forebrain, the …

HIV-associated neurocognitive disorder (HAND) affects nearly half of all HIV-infected
individuals. Synaptodendritic damage correlates with neurocognitive decline in HAND, and …

Depression causes mental and physical changes which affect quality of life. It is estimated to
become the second most prevalent disease, but despite its commonness, the …

Alzheimer's disease (AD) is the most commonly diagnosed dementia but its underlying
pathological mechanisms still unclear. Neuroinflammation and secretion of cytokines such …

The neuroimmune system of the brain, which is comprised primarily of astrocytes and
microglia, regulates a variety of homeostatic mechanisms that underlie normal brain …

Anti-inflammatory cytokines are known to exert neuroprotective action ameliorating aberrant
neuronal network activity associated with inflammatory responses. Yet, it is still not fully …

TNF-α-converting enzyme, a member of the ADAM (A disintegrin and metalloproteinase)
protease family and also known as ADAM17, regulates inflammation and regeneration in …

The role of the pro-inflammatory cytokine interleukin-6 (IL-6) in the etiology of stress-induced
synaptic plasticity is yet unknown. We took advantage of a genetically modified mouse (TG) …

Central neurons express unique repertoires of secreted and transmembrane proteins that
define their synaptic connectivity. However, how these molecular programs are regulated …