The incidence of esophageal adenocarcinoma (EAC) has increased in recent decades, and
its 5-year survival rate is less than 20%. As a well-established precursor, patients with …

In the 1990s it was discovered that the enzyme dipeptidyl peptidase-4 (DPP-4) inactivates
the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent …

Importance Treatment advances in diabetes can meaningfully improve outcomes only if they
effectively reach the populations at risk. Objectives To evaluate whether the cascade of US …

A concise review covering updated presence and role of 2-phenethylamines in medicinal
chemistry is presented. Open-chain, flexible alicyclic amine derivatives of this motif are …

Obesity and related metabolic syndromes have been recognized as important disease risks,
in which the role of adipokines cannot be ignored. Adiponectin (ADP) is one of the key …

DPP4/CD26 is a single-pass transmembrane protein with multiple functions on glycemic
control, cell migration and proliferation, and the immune system, among others. It has …

The prevalence of type 2 diabetes is increasing, which is alarming because of its serious
complications. Anti‐diabetic treatment aims to control glucose homeostasis as tightly as …

Background Cardiovascular (CV) outcome trials in type 2 diabetes (T2D) have
underrepresented patients with chronic kidney disease (CKD), leading to uncertainty …

Abstract Type 2 Diabetes Mellitus (T2DM) is one of the highly prevalence disorder and
increasing day by day worldwidely. T2DM is a metabolic disorder, which is characterized by …

Animal and human mechanistic studies have consistently shown an association between
obesity and Alzheimer's disease (AD). AD, a degenerative brain disease, is the most …