This review takes an inclusive approach to microvascular dysfunction in diabetes mellitus
and cardiometabolic disease. In virtually every organ, dynamic interactions between the …

Reperfusion injury, the paradoxical tissue response that is manifested by blood flow-
deprived and oxygen-starved organs following the restoration of blood flow and tissue …

The endothelial cells lining the brain capillaries separate the blood from the brain
parenchyma. The endothelial monolayer of the brain capillaries serves both as a crucial …

The interface between the blood circulation and the neural tissue features unique
characteristics that are encompassed by the term'blood-brain barrier'(BBB). The main …

The neurovascular unit is a complex, interdependent system composed of neurons and
neural supporting cells, such as astrocytes, as well as cells that comprise the vascular …

The cerebral hyperaemia is one of the fundamental mechanisms for the central nervous
system homeostasis. Due also to this mechanism, oxygen and nutrients are maintained in …

Treatment of certain central nervous system disorders, including different types of cerebral
malignancies, is limited by traditional oral or systemic administrations of therapeutic drugs …

Our understanding of BBB breakdown acutely after the cerebrovascular injury has come a
long way; however, we lack a clear understanding of the course of BBB disruption and BBB …

During the research and development of new drugs directed at the central nervous system,
there is a considerable attrition rate caused by their hampered access to the brain by the …

The blood-brain barrier (BBB) restricts the uptake of many neuro-therapeutic molecules,
presenting a formidable hurdle to drug development in brain diseases. We proposed a new …