Decoding stem cells: an overview on planarian stem cell heterogeneity and lineage progression

MD Molina, F Cebrià - Biomolecules, 2021 - mdpi.com
Planarians are flatworms capable of whole-body regeneration, able to regrow any missing
body part after injury or amputation. The extraordinary regenerative capacity of planarians is …

Ultrafast distant wound response is essential for whole-body regeneration

Y Fan, C Chai, P Li, X Zou, JE Ferrell, B Wang - Cell, 2023 - cell.com
Injury induces systemic responses, but their functions remain elusive. Mechanisms that can
rapidly synchronize wound responses through long distances are also mostly unknown …

Cellular diversity and developmental hierarchy in the planarian nervous system

LS Wyss, SR Bray, B Wang - Current opinion in genetics & development, 2022 - Elsevier
Our ability to dissect cell type diversity, development, and plasticity in the nervous system
has been transformed by the recent surge of massive sequencing studies at the single-cell …

[HTML][HTML] The known, unknown, and unknown unknowns of cell-cell communication in planarian regeneration

JJ Chen, K Lei - Zoological Research, 2023 - ncbi.nlm.nih.gov
Planarians represent the most primitive bilateral triploblastic animals. Most planarian
species exhibit mechanisms for whole-body regeneration, exemplified by the regeneration …

Neurophysiological measurements of planarian brain activity: a unique model for neuroscience research

O Benita, N Nesher, T Shomrat - Biology Open, 2024 - journals.biologists.com
Planarians are well-known model organisms for regeneration and developmental biology
research due to their remarkable regenerative capacity. Here, we aim to advocate for the …

The planarian flatworm Schmidtea mediterranea

L Drees, JC Rink - Nature Methods, 2023 - nature.com
The amazing regenerative abilities of many planarian species have been known for more
than 200 years. Thomas Hunt Morgan reported in 1898 that an estimated 279th of a whole …

Isolation of planarian viable cells using fluorescence‐activated cell sorting for advancing single‐cell transcriptome analysis

Y Kuroki, K Agata - Genes to Cells, 2023 - Wiley Online Library
Preparing viable single cells is critical for conducting single‐cell RNA sequencing (scRNA‐
seq) because the presence of ambient RNA from dead or damaged cells can interfere with …

[HTML][HTML] Adaptive robustness through incoherent signaling mechanisms in a regenerative brain

SR Bray, LS Wyss, C Chai, ME Lozada, B Wang - Cell Reports, 2024 - cell.com
Animal behavior emerges from collective dynamics of neurons, making it vulnerable to
damage. Paradoxically, many organisms exhibit a remarkable ability to maintain significant …

mRNA Transfection of S. mediterranea for Luminescence Analysis

U Weill, RN Hall, L Drees, B Wang, JC Rink - … mediterranea: methods and …, 2023 - Springer
Planarians have become a powerful model system for stem cell research and regeneration.
While the tool kit for mechanistic investigations has been steadily expanding over the last …

Regeneration leads to global tissue rejuvenation in aging sexual planarians

X Dai, X Li, S Pletcher, D Paris, L Kruglyak, J Sobota… - bioRxiv, 2023 - biorxiv.org
An ability to delay aging or to reverse the negative effects of aging could prevent age-related
disease and greatly enhance quality of life in old age. However, whether it is possible to …