The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …

Alzheimer's disease, the most prevalent form of dementia in the elderly, is characterized by
progressive memory loss and cognitive dysfunction. It has become increasingly clear that …

Alzheimer disease (AD) is the most common neurodegenerative disease. An imbalance
between the production and clearance of Aβ (amyloid beta) is considered to be actively …

Quantification and detection of the hierarchical organization of behavior is a major challenge
in neuroscience. Recent advances in markerless pose estimation enable the visualization of …

Stress is critically involved in the development and progression of disease. From the stress
of undergoing treatments to facing your own mortality, the physiological processes that …

Background Amyloid plaques, a pathological hallmark of Alzheimer's disease (AD), are
accompanied by activated microglia. The role of activated microglia in the pathogenesis of …

Alzheimer's disease (AD) pathology is commonly associated with cognitive decline but is
also composed of neuropsychiatric symptoms including psychological distress and …

Mice co‐expressing the Swedish amyloid precursor protein mutation (APPSwe) and exon 9
deletion (ΔE9) of the PSEN1 gene begin to develop amyloid plaques at 6–7 months of age …

Abstract Rationale Patients suffering from Alzheimer's disease (AD) exhibit a decline in
cognitive abilities including an inability to recognise familiar faces. Hallmark pathological …

Introduction Despite the extensive mechanistic and pathological characterization of the
amyloid precursor protein (APP)/presenilin-1 (PS-1) knock-in mouse model of Alzheimer's …