Anatomists involved with studies of the hippocampal formation are being prodded by
computational modelers and physiologists who demand detailed and quantitative …

Factors which limit the interpretation of studies of aging brain include: secular trends,
species and strain differences, effects of tissue processing, and bias which may be …

We have determined the biochemical and immunocytochemical localization of the
heterogeneous microtubule-associated protein tau using a monoclonal antibody that binds …

One of the major neuropathological findings in the brains of individuals with Alzheimer's
disease (AD) is a loss of synaptic contacts in both the neocortex and hippocampus. Here we …

We have found that the density of synapses in the stratum radiatum of the hippocampal CA1
region in the adult female rat is sensitive to estradiol manipulation and fluctuates naturally as …

Neuronal activity is an essential stimulus for induction of plasticity and normal development
of the CNS. We have used differential cloning techniques to identify a novel immediate-early …

Golgi impregnations of neostriatum from deceased Huntington's disease patients and
controls were examined. In all cases of Huntington's disease the morphology of dendrites of …

The regenerative capacity of the CNS is extremely limited. The reason for this is unclear, but
glial cell involvement has been suspected, and oligodendrocytes have been implicated as …

This study was designed to identify whether synaptic reorganizations occur in epileptic
human hippocampus which might contribute to feedback excitation. In epileptic …

Neurons transmit and receive information at specialized junctions called synapses.
Excitatory synapses form at the junction between a presynaptic axon terminal and a …