Cre/LoxP has broad utility for studying the function, development, and oncogenic
transformation of pancreatic cells in mice. Here we provide an overview of the Cre driver …

Neurons of the dorsal hindbrain and spinal cord are central in receiving, processing and
relaying sensory perception and participate in the coordination of sensory-motor output …

Human pluripotent stem cells (hPSCs) have opened new opportunities for understanding
human development, modelling disease processes and developing new therapeutics …

Neural tube (NT) defects arise from abnormal neurulation and result in the most common
birth defects worldwide. Yet, mechanisms of primate neurulation remain largely unknown …

In many developing tissues, the patterns of gene expression that assign cell fate are
organized by graded secreted signals. Cis-regulatory elements (CREs) interpret these …

Bipolar disorder (BP) is a chronic psychiatric condition characterized by dynamic,
pathological mood fluctuations from mania to depression. To date, a major challenge in …

In the vertebrate neural tube, regional Sonic hedgehog (Shh) signaling invokes a time-and
concentration-dependent induction of six different cell populations mediated through Gli …

Genetic or pharmacological activation of canonical Wnt/β-catenin signaling inhibits
oligodendrocyte differentiation. Transcription factor 7-like 2 (TCF7l2), also known as TCF4 …

Cell fate specification in the CNS is controlled by the secreted morphogen sonic hedgehog
(Shh). At spinal cord levels, Shh produced by both the notochord and floor plate (FP) …

Major nonprimate-primate differences in corticogenesis include the dimensions, precursor
lineages, and developmental timing of the germinal zones (GZs). microRNAs (miRNAs) of …