A functional vascular system is indispensable for drug delivery and fundamental for
responsiveness of the tumour microenvironment to such medication. At the same time, the …

Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the retina and a leading
cause of visual impairment and childhood blindness worldwide. The disease is …

OBJECTIVE Diabetic retinopathy (DR) is a leading cause of blindness. Increased vascular
endothelial growth factor (VEGF), promoting angiogenesis and increased permeability, is a …

Roughly ten years ago the FDA approved most of the presently used anti-VEGF drugs for the
treatment of neovascular AMD and other eye pathologies characterized by ocular …

Diabetic retinopathy is the leading cause of visual impairment and preventable blindness,
and represents a significant socioeconomic cost for health care systems worldwide …

Sex differences in neurological disease extend from incidence, severity, progression and
symptoms and may ultimately influence treatment. Cognitive disturbances are frequent in …

Patients struggling with diabetes are at elevated risks for several sight-threatening diseases,
including proliferative diabetic retinopathy (DR). DR manifests in two stages: first, the retinal …

Background Altered expression levels and structural variations in the vascular endothelial
growth factor (VEGF) have been found to play important roles in cancer development and to …

Diabetic nephropathy is the leading cause of ESRD in high-income countries and a growing
problem across the world. Vascular endothelial growth factor-A (VEGF-A) is thought to be a …

Trophic factors are endogenously secreted proteins that act in an autocrine and/or paracrine
fashion to affect vital cellular processes such as proliferation, differentiation, and …