Therapeutic potential of bacteriophage endolysins for infections caused by Gram-positive bacteria

H Liu, Z Hu, M Li, Y Yang, S Lu, X Rao - Journal of biomedical science, 2023 - Springer
Abstract Gram-positive (G+) bacterial infection is a great burden to both healthcare and
community medical resources. As a result of the increasing prevalence of multidrug-resistant …

[HTML][HTML] Design strategies for positively charged endolysins: insights into Artilysin development

JV Carratalá, A Arís, E Garcia-Fruitós… - Biotechnology …, 2023 - Elsevier
Endolysins are bacteriophage-encoded enzymes that can specifically degrade the
peptidoglycan layer of bacterial cell wall, making them an attractive tool for the development …

Bactericidal synergism between phage endolysin Ply2660 and cathelicidin LL-37 against vancomycin-resistant Enterococcus faecalis biofilms

H Zhang, X Zhang, S Liang, J Wang, Y Zhu… - npj Biofilms and …, 2023 - nature.com
Antibiotic resistance and the ability to form biofilms of Enterococcus faecalis have
compromised the choice of therapeutic options, which triggered the search for new …

Characterization of a novel bacteriophage endolysin (LysAB1245) with extended lytic activity against distinct capsular types associated with Acinetobacter baumannii …

R Soontarach, P Srimanote, B Arechanajan… - Plos one, 2024 - journals.plos.org
Capsular polysaccharides are considered as major virulence factors associated with the
ability of multidrug-resistant (MDR) Acinetobacter baumannii to cause severe infections. In …

Characterization of a Peptidoglycan-Degrading Protein: Biochemical and Antimicrobial Characteristics, Antibiotic Synergism, and Delivery System Innovation

VC Oliveira, NG Rosa-Garzon, ACSD Rocha… - Probiotics and …, 2024 - Springer
The global health threat posed by antibiotic resistance has led to new research involving
bacteriophage-encoded enzymes. This study characterized a new peptidoglycan-degrading …

Bacteriophage-Based Bioanalysis

DR Parker, SR Nugen - Annual Review of Analytical Chemistry, 2024 - annualreviews.org
Bacteriophages, which are viral predators of bacteria, have evolved to efficiently recognize,
bind, infect, and lyse their host, resulting in the release of tens to hundreds of propagated …

Role of hypothetical protein PA1-LRP in antibacterial activity of endolysin from a new Pantoea phage PA1

Y Tian, X Xu, M Ijaz, Y Shen, MS Shahid… - Frontiers in …, 2024 - frontiersin.org
Introduction Pantoea ananatis has emerged as a significant plant pathogen affecting various
crops worldwide, causing substantial economic losses. Bacteriophages and their endolysins …

[HTML][HTML] Endolysin CHAP domain-carbosilane metallodendrimer complexes with triple action on Gram-negative bacteria: Membrane destabilization, reactive oxygen …

K Lach, K Skrzyniarz, S Takvor-Mena… - International Journal of …, 2024 - Elsevier
Bacterial resistance to antibiotics is a significant challenge that is associated with increased
morbidity and mortality. Gram-negative bacteria are particularly problematic due to an outer …

Cellular and Enzymatic Determinants Impacting the Exolytic Action of an Anti-Staphylococcal Enzybiotic

A Gouveia, D Pinto, JMB Vítor, C São-José - International Journal of …, 2023 - mdpi.com
Bacteriophage endolysins are bacteriolytic enzymes that have been explored as potential
weapons to fight antibiotic-resistant bacteria. Despite several studies support the application …

Delivery of endolysin across outer membrane of Gram-negative bacteria using translocation domain of botulinum neurotoxin

W Park, M Park, J Chun, J Hwang, S Kim, N Choi… - International Journal of …, 2024 - Elsevier
The emergence of multidrug-resistant pathogens has outpaced the development of new
antibiotics, leading to renewed interest in endolysins. Endolysins have been investigated as …