The prediction of preeclampsia: the way forward

L Myatt - American journal of obstetrics and gynecology, 2022 - Elsevier
Despite intensive investigation, we still cannot adequately predict, treat, or prevent
preeclampsia. We have gained awareness that preeclampsia is a syndrome not a disease …

Pregnancy, preeclampsia and maternal aging: From epidemiology to functional genomics

EC Miller, A Wilczek, NA Bello, S Tom, R Wapner… - Ageing research …, 2022 - Elsevier
Women live longer than men but experience greater disability and a longer period of illness
as they age. Despite clear sex differences in aging, the impact of pregnancy and its …

Incident coronary heart disease after preeclampsia: role of reduced fetal growth, preterm delivery, and parity

HKR Riise, G Sulo, GS Tell, J Igland… - Journal of the …, 2017 - Am Heart Assoc
Background Preeclampsia is a severe pregnancy disorder often complicated by reduced
fetal growth or preterm delivery and is associated with long‐term maternal morbidity and …

Hypertensive pregnancy disorders increase the risk of maternal cardiovascular disease after adjustment for cardiovascular risk factors

HKR Riise, G Sulo, GS Tell, J Igland, G Egeland… - International journal of …, 2019 - Elsevier
Background and aim Hypertensive pregnancy disorders are associated with subsequent
cardiovascular disease (CVD), but the extent to which this association is explained by …

Gene-Centric Analysis of Preeclampsia Identifies Maternal Association at PLEKHG1

KJ Gray, VP Kovacheva, H Mirzakhani, AC Bjonnes… - …, 2018 - Am Heart Assoc
The genetic susceptibility to preeclampsia, a pregnancy-specific complication with
significant maternal and fetal morbidity, has been poorly characterized. To identify maternal …

Risk of pre‐eclampsia in patients with a maternal genetic predisposition to common medical conditions: a case–control study

KJ Gray, VP Kovacheva, H Mirzakhani… - … Journal of Obstetrics …, 2021 - Wiley Online Library
Objective To assess whether women with a genetic predisposition to medical conditions
known to increase pre‐eclampsia risk have an increased risk of pre‐eclampsia in …

Whole-exome sequencing in multiplex preeclampsia families identifies novel candidate susceptibility genes

PE Melton, MP Johnson, D Gokhale-Agashe… - Journal of …, 2019 - journals.lww.com
Objective: Preeclampsia is a common and serious heritable disorder of human pregnancy.
Although there have been notable successes in identification of maternal susceptibility …

[HTML][HTML] Evaluation of epigenetic age calculators between preeclampsia and normotensive pregnancies in an Australian cohort

P Pruszkowska-Przybylska, S Brennecke, EK Moses… - Scientific Reports, 2022 - nature.com
Advanced biological aging, as assessed through DNA methylation markers, is associated
with several complex diseases. The associations between maternal DNA methylation age …

[HTML][HTML] The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsia

LCV Thomsen, NS McCarthy, PE Melton… - Journal of …, 2017 - journals.lww.com
Objective: Preeclampsia is a complex heterogeneous disease commonly defined by new-
onset hypertension and proteinuria in pregnancy. Women experiencing preeclampsia have …

A meta-analysis of the vascular endothelial growth factor polymorphisms associated with the risk of pre-eclampsia

W Duan, C Xia, K Wang, Y Duan, P Cheng… - Bioscience …, 2020 - portlandpress.com
Abstract Backgroud: Pre-eclampsia (PE) is a common pregnancy-induced hypertension
disease. Some case–control studies reported the association between vascular endothelial …