The roles of matrix metalloproteinases and their inhibitors in human diseases

GA Cabral-Pacheco, I Garza-Veloz… - International journal of …, 2020 - mdpi.com
Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM)
remodeling endopeptidases that have the capacity to degrade almost every component of …

Matrix metalloproteinases, vascular remodeling, and vascular disease

X Wang, RA Khalil - Advances in pharmacology, 2018 - Elsevier
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …

Matrix metalloproteinases in normal pregnancy and preeclampsia

J Chen, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Normal pregnancy is associated with marked hemodynamic and uterine changes that allow
adequate uteroplacental blood flow and uterine expansion for the growing fetus. These …

Pathogenesis of preeclampsia and therapeutic approaches targeting the placenta

MK Jena, NR Sharma, M Petitt, D Maulik, NR Nayak - Biomolecules, 2020 - mdpi.com
Preeclampsia (PE) is a serious pregnancy complication, affecting about 5–7% of
pregnancies worldwide and is characterized by hypertension and damage to multiple …

Vascular mechanisms and molecular targets in hypertensive pregnancy and preeclampsia

H Qu, RA Khalil - American Journal of Physiology-Heart and …, 2020 - journals.physiology.org
Preeclampsia is a major complication of pregnancy manifested as hypertension and often
intrauterine growth restriction, but the underlying pathophysiological mechanisms are …

Mechanisms of endothelial dysfunction in hypertensive pregnancy and preeclampsia

JS Possomato-Vieira, RA Khalil - Advances in pharmacology, 2016 - Elsevier
Preeclampsia is a pregnancy-related disorder characterized by hypertension and could lead
to maternal and fetal morbidity and mortality. Although the causative factors and …

Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia

DA Shah, RA Khalil - Biochemical pharmacology, 2015 - Elsevier
Preeclampsia is a pregnancy-associated disorder characterized by hypertension, and could
lead to maternal and fetal morbidity and mortality; however, the pathophysiological …

Role of gelatinases MMP-2 and MMP-9 in healthy and complicated pregnancy and their future potential as preeclampsia biomarkers

A Nikolov, N Popovski - Diagnostics, 2021 - mdpi.com
Gelatinases (matrix metalloproteinase-2 and-9) are enzymes from the matrix
metalloproteinases (MMPs) family, which are associated with collagen degradation. MMP-2 …

[HTML][HTML] Cellular and molecular regulation of spiral artery remodelling: lessons from the cardiovascular field

GSJ Whitley, JE Cartwright - Placenta, 2010 - Elsevier
A number of important changes take place in the maternal uterine vasculature during the first
few weeks of pregnancy resulting in increased blood flow to the intervillous space. Vascular …

Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease

MM Benjamin, RA Khalil - … Inhibitors: Specificity of Binding and Structure …, 2012 - Springer
Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade various
components of the extracellular matrix (ECM). MMPs could also regulate the activity of …