Research into novel methods for otitis media pathophysiology, diagnosis and treatment has
seen great strides in the recent past. Avenues towards markedly altering the evaluation and …

The microbiota of the upper respiratory tract (URT) protects the host from bacterial
pathogenic colonization by competing for adherence to epithelial cells and by immune …

Leveraging linkage disequilibrium (LD) patterns as representative of population substructure
enables the discovery of additive association signals in genome-wide association studies …

Abstract Background Human milk oligosaccharides (HMOs) are an abundant class of
compounds found in human milk and have been linked to the development of the infant, and …

Highlights•Cells other than leukocytes can be essential for protective immunity in
humans.•Human inborn errors of immunity to infection can affect non-professional cells …

Humans homozygous or hemizygous for variants predicted to cause a loss of function (LoF)
of the corresponding protein do not necessarily present with overt clinical phenotypes. We …

Background Otitis media (OM) susceptibility has significant heritability; however, the role of
rare variants in OM is mostly unknown. Our goal is to identify novel rare variants that confer …

Otitis media (OM) is a leading cause of childhood hearing loss. Variants in FUT2, which
encodes alpha-(1, 2)-fucosyltransferase, were identified to increase susceptibility to OM …

Otitis media (OM) is an infective and inflammatory disorder known to be a major cause of
hearing impairment across all age groups. Both acute and chronic OM result in substantial …

Objective To perform a comprehensive review of the literature from July 2015 to June 2019
on the pathogenesis of otitis media. Bacteria, viruses and the role of the microbiome as well …