Mitochondria are best known for harboring pathways involved in ATP synthesis through the
tricarboxylic acid cycle and oxidative phosphorylation. Major advances in understanding …

Caenorhabditis elegans is an important model organism with many useful features,
including rapid development and aging, easy cultivation, and genetic tractability. Survival …

Mitochondrial dysfunction is at the core of many diseases ranging from inherited metabolic
diseases to common conditions that are associated with aging. Although associations …

Retrograded starch is known to be resistant to digestion. We used enzyme kinetic
experiments to examine how retrogradation of starch affects amylolysis catalysed by porcine …

Moderate stress can increase lifespan by hormesis, a beneficial low-level induction of stress
response pathways. 5′-fluorodeoxyuridine (FUdR) is commonly used to sterilize …

Triphenyl phosphate (TPHP) is a widely used aryl organophosphate flame retardant (OPFR)
that has attracted attention due to its frequent detection in the environment and living …

To expand the understanding of aging in the model organism Caenorhabditis elegans,
global quantification of metabolite and protein levels in young and aged nematodes was …

Neurodegeneration has been correlated with mitochondrial DNA (mtDNA) damage and
exposure to environmental toxins, but causation is unclear. We investigated the ability of …

Caenorhabditis elegans is a valuable model organism in biomedical research that has led to
major discoveries in the fields of neurodegeneration, cancer and aging. Because movement …

Introduction Aging represents a major risk factors for metabolic diseases, such as diabetes,
obesity, or neurodegeneration. Polyphenols and their metabolites, especially simple …