Dilated cardiomyopathy is conventionally defined as the presence of left ventricular or
biventricular dilatation or systolic dysfunction in the absence of abnormal loading conditions …

Cardiotoxicity is the main side effect of several chemotherapeutic drugs. Doxorubicin (Doxo)
is one of the most used anthracyclines in the treatment of many tumors, but the development …

Polyguluronic acid (PG), a polysaccharide from alginate, possesses excellent bioactivities.
We prepared high-purity PG with 10.41 kDa molecular weight (Mw) and a 59 average …

Due to the cardiotoxicity of doxorubicin (DOX), its clinical application is limited. Lipid
peroxidation caused by excessive ferrous iron is believed to be a key molecular mechanism …

Doxorubicin (DOX) is a potent chemotherapeutic agent used against several cancer types.
However, due to its cardiotoxic adverse effects, the use of this drug may be also life …

Clinically, cardiac dysfunction is a key component of sepsis-induced multi-organ failure.
Mitochondria are essential for cardiomyocyte homeostasis, as disruption of mitochondrial …

Cardiotoxicity remains a major limitation in the clinical utility of anthracycline
chemotherapeutics. Regulator of G-protein Signaling 7 (RGS7) and inflammatory markers …

Sodium–glucose cotransporter 2 inhibitors (SGLT2i), a new drug class initially designed and
approved for treatment of diabetes mellitus, have been shown to exert pleiotropic metabolic …

Doxorubicin (DOX) is an anthracycline chemotherapy drug widely employed in the treatment
of various cancers, known for its potent antineoplastic properties but often associated with …

Doxorubicin, the most prescribed chemotherapeutic drug, causes dose-dependent
cardiotoxicity and heart failure. However, our understanding of the immune response elicited …