Abstract MCL1 (myeloid cell leukemia-1) is a widely recognized pro-survival member of the
Bcl-2 (B-cell lymphoma protein 2) family and a promising target for cancer therapy. While the …

Local Ca2+ transfer between adjoining domains of the sarcoendoplasmic reticulum (ER/SR)
and mitochondria allows ER/SR Ca2+ release to activate mitochondrial Ca2+ uptake and to …

To maintain homeostasis, every cell must constantly monitor its energy level and
appropriately adjust energy, in the form of ATP, production rates based on metabolic …

Bcl-2 family members are important regulators of cell survival and cell death. Researchers
have focused mainly on mitochondria, where both proapoptotic and antiapoptotic family …

Bcl-2 family proteins are considered as one of the major regulators of apoptosis. Indeed, this
family is known to control the mitochondrial outer membrane permeabilization (MOMP): a …

Calcium is a versatile and dynamic 2nd messenger that is essential for the survival of all
higher organisms. In cells that undergo activation or excitation, calcium is released from the …

When cellular organelles communicate bad things can happen. Recent findings uncovered
that the junction between the endoplasmic reticulum (ER) and the mitochondria holds a …

Bcl-2 proteins are widely known as key controllers of mitochondrial outer membrane
permeabilization, arguably the most important step of intrinsic apoptosis. Accumulating …

The amount of Ca2+ taken up in the mitochondrial matrix is a crucial determinant of cell fate;
it plays a decisive role in the choice of the cell between life and death. The Ca2+ ions mainly …

The most prominent function of proteins of the Bcl-2 family is regulation of the initiation of
intrinsic (mitochondrial) pathways of apoptosis. However, recent research has revealed that …