Abstract Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation
of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell …

This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …

Sulforaphane (SFN), a potent nuclear factor erythroid 2-related factor 2 (Nrf2) activator, is
present in the species of the Brassicaceae, especially in broccoli sprouts. In this study, the …

Nonalcoholic steatohepatitis (NASH) is emerging as a leading cause of chronic liver
disease. However, therapeutic options are limited by incomplete understanding of the …

The occurrence of neuroactive chemicals in the aquatic environment is on the rise and
poses a potential threat to aquatic biota of currently unpredictable outcome. In particular …

Targeted drugs have changed cancer treatment but are often ineffective in the long term
against solid tumours, largely because of the activation of heterogeneous oncogenic …

Proline is unique in the realm of amino acids in its ability to adopt completely distinct cis and
trans conformations, which allows it to act as a backbone switch that is controlled by prolyl …

Protein phosphorylation regulates many cellular processes by causing changes in protein
conformation. The prolyl isomerase PIN1 has been identified as a regulator of …

Pin1 is a highly conserved enzyme that only isomerizes specific phosphorylated Ser/Thr-Pro
bonds in certain proteins, thereby inducing conformational changes. Such conformational …

The unique oncogene duet of coexisting BRAF V600E and TERT promoter mutations are
widely found to be a robust genetic background promoting human cancer aggressiveness …