Viewing metabolism through the lens of exercise biology has proven an accessible and
practical strategy to gain new insights into local and systemic metabolic regulation. Recent …

The continual supply of ATP to the fundamental cellular processes that underpin skeletal
muscle contraction during exercise is essential for sports performance in events lasting …

Background Muscle wasting and weakness in Duchenne muscular dystrophy (DMD) causes
severe locomotor limitations and early death due in part to respiratory muscle failure. Given …

A growing body of research is investigating the potential contribution of mitochondrial
function to the etiology of type 2 diabetes. Numerous in vitro, in situ, and in vivo …

Key points Following fish oil supplementation, omega‐3 fatty acids are incorporated into
cellular membranes, which may affect lipid–protein interactions and therefore the function of …

It remains unknown if mitochondrial bioenergetics are altered with aging in humans. We
established an in vitro method to simultaneously determine mitochondrial respiration and H …

Magnetic resonance spectroscopy (MRS) can give information about cellular metabolism in
vivo which is difficult to obtain in other ways. In skeletal muscle, non‐invasive 31 P MRS …

Key points Oral consumption of nitrate (NO3−) in beetroot juice has been shown to decrease
the oxygen cost of submaximal exercise; however, the mechanism of action remains …

Although molecular approaches altering mitochondrial content have implied a direct
relationship between mitochondrial bioenergetics and insulin sensitivity, paradoxically …

Mitochondrial bioenergetic contributions to sex differences in human skeletal muscle
metabolism remain poorly defined. The primary aim of this study was to determine whether …